The Correlation Between L-selectin And P388D1 Cell Line Metastasis Potency To Peripheral Lymph Nodes

L-, P-, and E-selectins comprise a family of carbohydrate-binding adhesion molecules expressed by leukocytes and platelets and vascular endothelium. L-selectin (CD62L) is a lymphocyte homing receptor, which constitutively expressed on all neutrophils and monocytes, on subsets of blood borne T cells, B cells, natural killer (NK) cells and tumor cells. The ligands of L-selectin include CD34, sgp200, endomucin and GlyCAM-1. They not only reside in leukocyte, but also in many type tumor cells, which participate tumor metastasis.It has been demonstrated that solid tumor occurred in regional lymphaden disseminateion. The normal function of L-selectin is homing receptor, and L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis. Lack of L-selectin expression in the host significantly delayed the dissemination of lymphomas to peripheral tissues. This resistance of L-selectin-deficient mice to lymphoma metastasis was dependent on the intrinsic properties of lymphoma cells. This work provided definitive evidence that L-selectin play a significant role at different steps of T cell lymphoma development. But, this idea has been challenged by studies that have shown a lack of correlation between the expressions of L-selectin with the metastatic potential of lymphoma cells. Nevertheless, the way that L-selectin function in vivo and in vitro is not fully understood and numerous questions remain unanswered concerning the physiology and function. Therefore, it is conceivable that any tumor cell could randomly activate expression of L-selectin during tumor progression, and it is worth exploring a potential role of L-selectin in LN metastases of lymphoid tumors.