Heparin Inhibits Lymphogenous Metastasis Of P388D1 Cell Line

Tumor is the most serious disease to human being , the malignancy degree is mainly determined by the tumor cells'metastasis ability. Tumor cells scattered from the originate loci, intruded into the lymph vessel,blood vessel,coelom,migrated to other tissues or organs , formed new metastatic tumor. Tumors'metastasis is a complex process which is affected by many factors. Adhesion to the endothelium of blood or lymph vessels is a important step to the metastasis of tumor cells. Metastasis through lymph vessel is a early and very important way of tumor cells and also used as a valuable index to grade patients'prognosis and select treatment plan in clinic. So to research the mechanism of lymphatic metastasis and prohibit it is of great importance to improving patients'life quality and prolonging patients'lifetime. Cellular adhesion molecule L-selectin is a member of selectin family. L-selectin persistantly expresses on the surface of a large number of white blood cells, and is the"homing receptor"of lymph cells. In addition, it plays a significant role in tumor's lymphatic metastasis,inflammatory reaction,organ transplantation,immunological rejection et al. Fawn Qian's group injected tumor cells into transgenic mice and found only the tumor cells which expressed L-selectin can be detected in peripheral lymph node. This experiment demonstrated that L-selectin can facilitated metastasis of tumor cells to lymph node. Borsig's group found that the endogenous L-selectin which express on the surface of WBC have an effect on the transfer behavior of colon carcinoma, so we concluded that L-selectin indeed have an effect on tumor's lymphatic metastasisHeparin, which is a member of polycose family, is a sulfating...