Effect And Mechanism Of Cyclooxygenase Inhibitors On The Proleferation, Apoptosis, Angiogenesis And Invasion In Epithelial Ovarian Carcinoma

Epithelial Ovarian carcinoma represents a troublesome disease that typically has progressed to an advanced stage at the time of diagnosis. Traditional treatment, such as debulking surgery, chemotherapy and radiotherapy had little impact on the long-term survival rates. Screening strategies have suffered from high rates of false positive tests and have not proved to be useful clinically'~[1,2]. Therefore, to attain the goal of reduction of the death rate, chemoprevention and new treatment strategy of ovarian carcinoma represent the most rational ways~[1] .chemoprevention has been investigated in a variety of other solid tumors, chemoprevention trials in breast, colon, head and neck, and liver cancers suggest the potential utility of such an approach using a variety of agents~[3-7] Additionally, utilization of nonsteroidal anti-inflammatory drugs (NSAIDs) in familial polyposis suggested the ability of chemopreventive agents to interrupt the sequence of carcinogenic events leading to an invasive malignancy~[3,8].Epidemiological and experimental data have supported the use of NSAIDs as potential chemopreventive agents in a variety of types of cancer. Although some epidemiological data indicated that NSAIDS could be effective in the prevention of ovarian cancers~[9,10], little data were available regarding the effects of NSAIDS on cell lines of ovarian carcinoma. Therefore, we evaluated four common types of NSAIDs and one COX-2 selective inhibitor - NS398 in regard to their effects on the proliferation, apoptosis, angiogenesis and invasion of ovarian tumor cells.OBJECTIVES 1. To investigate the effect and mechanism of COX inhibitors on the cell...