Effects Of Carbon Monoxide Inhaled On The Inflammation In Lung Of Rat With Acute Lung Injury-induced By Lipopolysaccharide

Section 1: Effects of carbon monoxide inhaled on arterial oxygenation of rats with acute lung injury induced by lipopolysaccharideObjective: To observe the effects of carbon monoxide (CO) inhaled on arterial oxygenation and carboxyhemoglobin (COHb) level of rats with acute lung injury (ALI) induced by lipopolysaccharide (LPS). Methods: Seventy-two male Sprague-Dawley rats were randomly divided into four groups. Drugs were injected by intravenous. Control group received normal saline, CO inhaled alone group received an inhalation 250 ppm CO, ALI group received 5 mg.kg^-1 LPS, ALI+CO inhaled group received an inhalation of 250 ppm CO after ALI induced by 5 mg.kg^-1 LPS injected. The animals were sacrificed by exsanguinations at 1,3 and 6 h of the observation in four groups. Arterial blood was harvested for determinating the partial pressure of arterial oxygen (PaO₂), saturation of arterial oxygen (SaO₂) and COHb level. Results: PaO₂ and SaO₂ of four groups had statistics difference in neither the same time point of groups nor the differential time point of the same group. COHb of CO inhaled alone group and ALI+CO inhaled group was significantly increased compared with control group at the same time point (all P<0.05). At the same time point, COHb of CO inhaled alone and ALI+CO inhaled group was markedly increased compared...