The Experiment Study Of The Protective Effects Of Low Concentration Carbon Monoxide Inhaled In Rats With Acute Lung Injury Induced By Lipopolysaccharide

Objective: Acute lung injury (ALI) is a common clinical disorder characterized by injury of the alveolar epithelial and endothelial barriers, increased permeability, leucocyte accumulation, decreased lung compliance, pulmonary hyaline membrane formation and protein rich pulmonary edema that is not the result of congestive heart failure, leading to acute hypoxemic respiratory failure. With the research going on deeply, we have a deepgoing recognition about the pathophysiology, diagnosis and treatment of ALI/ARDS. It is generally believed that ALI is a kind of inflammation, as well as the pulmonary inflammation in systemic inflammation response syndrome (SIRS). Imbalance of inflammation factors plays an important role in the occurrence and development of ALI. Carbon monoxide (CO) is another important signaling molecule after the discovery of NO, participating in the regulation of multiple physiological and pathological process, including inflammatory reaction. We establish the model of ALI in rats induced by intravenous lipopolysaccharide (LPS) via the tail vein, to observe the effects of low concentration carbon monoxide (CO) inhaled on TNF-α and IL-10 levels in rats with acute lung injury and afford a new thinking for the treatment of ALI and other inflammation diseases.Materials and Methods: Seventy-two male Sprague-Dawley rats were randomly divided into four groups, namely control group, CO group,...