The Immunoreactivity And Effect On Platelet Aggregation Of ITP IgG Antibody And Its Fragments

Thromboembolic diseases are a group of growing diseases which carry substantial morbidity and mortality. The therapeutic options for prevention and treatment of thromboembolic diseases are at the moment limited. Various factors have been established to contribute to the pathogenesis of thromboembolism, which include vascular endothelium injury, stasis of blood stream and fibrinolysis activity depression. While, platelets adhesion, activation and aggregation play pivotal roles in the pathogenesis, and anti-platelet therapy has become an important strategy in the prevention and treatment of thrombotic diseases.Platelets are small, anucleate blood cells derived from megakaryocytes. They provide the first line of defence following injury, forming thrombi that patch-up damaged tissue and thereby playing an indispensable role in haemostasis. However, inappropriate platelet activation can lead to thrombosis, myocardial infarction and strokes. Platelets are also believed to be involved in the development of atherosclerosis in coronary or carotid arteries, which is commonly the trigger for thrombosis. Platelets possess a variety of membrane glycoproteins (GPs) with related yet distinct functions. Among them, GPIIb/IIIa, GPIb/IX GPVI and GPIa/IIa play far more important roles than others. They participate in different stages of platelets...