Preparation Of Recombinant Heparin-binding Domain Polypeptide Of Fibronectin And Study Of In Vivo Effect Of The Polypeptide On Sepsis In Mice And On Disseminated Intravascular Coagulation In Rats

Sepsis and disseminated intravascular coagulation (DIC), acute severe syndromes were often seen in clinics. Infected shock induced by sepsis always caused DIC and DIC, in turn, might exacerbate the shock. DIC could cause serious bleeding and induce the function failure of multiple organs. Most of the patients with the disease died. FN, the major component of extracellular matrix, is known to be a large multifunction glycoprotein with binding sites for many substances, including heparin, collagen, fibrinogen, fibrin and integrin cell surface receptors. It is involved in a variety of cellular processes, including tissue repair, blood clotting and cell migration or adhesion. Many clinical studies of the disease suggested that plasma fibronectin (FN) concentration might contribute to the prognosis of infected shock complicated with DIC. A low plasma concentration of...