The Experimental And Clinical Studies Of Antiangiogenesis Therapy Combined With Radiotherapy On HCC

OBJECTIVEThere is abundant new vessel formation in the development of solid tumors. Neovascularization is an obligatory event connected with the growth, invasion and metastasis of tumors. Primary hepatocellular carcinoma(HCC) is one of the most common malignant hypervascular tumors characterized by neovascularization. Respond poorly to traditional treatments, recurrence and metastasis are common in HCC and associated with poor prognosis. Angiogenesis is triggered by a variety of growth factors and vascular endothelial growth factor(VEGF) is the principal regulator in the complex process of vessel formation. VEGF facilitates endothelial cell fission, proliferation and vessel construction, inducing angiogenesis, inhibiting apoptosis of endothelial cells, improving permeability of new blood vessel, promoting the expression and activity of enzymes in decomposing extracellular matrix and basement membrane. VEGF plays a pivotal role in the course of angiogenesis and tumor growth, invasion and metastasis.The mainstay of HCC treatments today consists of surgery, radiotherapy, and chemotherapy. Surgical treatment is the most effective method, but the great majority patients with HCC have no chance for surgical treatment when the disease was...