Advanced Oxidation Protein Products Induce Renal Damage In Diabetic Rat: Intervention Of Apocynin

Diabetes is the leading cause of end-stage renal disease worldwide. Although clinical studies have demonstrated a clear link between hyperglycemia and the development of diabetic complications of diabetes, the mechanisms through which excess glucose results in tissue damage remain incompletely understand. Accumulated evidence indicate that the over generation of reactive oxygen species(ROS) (oxidative stress) may play an important role in the etiology of diabetic complications. This hypothesis is supported by evidence indicating that many biochemical pathways strictly associated with hyperglycemia (glucose autoxidation, polyol pathway, prostanoid synthesis, protein glycation) can increase the production of free radicals. Accumulation of plasma advanced oxidation protein products (AOPPs) has been found firstly in patients with chronic kidney disease (CKD). AOPPs can be formed in vitro by exposure of serum albumin to hypochlorous acid...