Induction Of Apoptosis And Tumor Regression By Phenylisocyanate Derivative Of Quercetin

Quercetin( Que, 3,3',4',5,7-pentahydroxy flavone) a widely distributed bioflavonoid in the plant kingdom, has important effects on cancer chemoprevention and chemotherapy. As a result of its bad solubility in pharmaceutically acceptable solvents and bad pharmacokinetic properties that lead to the poor absorption/availability after oral administration of Quercetin and so badly affected the clinic development of Quercetin. Therefore it is significant to design and synthesize Quercetin derivatives with enhanced water solubility and better pharmacokinetic properties by structure modification on Quercetin. A novel Quercetin derivative(phenylisocyanate of Quercetin, PHICNQ) was synthesized using isocyanate as a intermediate in the phase transfer catalyst. The present study was designed to investigate whether PHICNQ potentiates the antitumor activity in vitro and in vivo.MethodsInhibition of proliferation of PHICNQ on K562 and CT26 tumor cells...