Studies On The Relationship Between Structure And Function Of Common β Chain (Bc) Of Human Interleukin-3 (IL-3), IL-5 And Granulocyte-Macrophage Colony-Stimulating Factor Receptors

Interleukin - 3 (IL-3) , IL - 5 and granulocyte -macrophage colony- stimulating factor (GM-CSF), which are produced by activated T cells, mast cells and many other types of cells, play important roles in hemopoie8is and immunoregulation of a wide variety of cells. All of the biologic activities of IL-3, IL—5 and GM-CSF are believed to be through the interaction of Ligand and receptors on target cells.Recent research indicated that high-affinity receptors for IL-3, IL-5 or GM-CSF are composed of two distinct subunits, a and 3 chain,both of which belong to the hemopoietin receptor superfamily. The a subunits of IL-3R, GM-CSFR or IL-5R...