Pathology And Mechanism Of The Disease In Hemorrhagic Fever With Renal Syndrome

Of the possible theroies of the mechanism of HFRS, the virus directly attacking and immunological-mediated pathogenesis of HFRS were highly valued. But the data reported so far could not give a comprenhensive explanation of the mechanism of the disease, in which the infected cells played a role and although the immune complexes had been demonstrated in large quantity in the serum and blood, scanty the deposits of IC or capillaries of tissues and glomerular tufts were in comparison with those seen in many types of glomerulonephrits, and also the specific IC containing viral antigens, antibodies and complements were less reported. So if IC played a role, there was no evidence that the deposits of IC on capillaries would be more relevant to pathogenesis than other partly unknown mechanism, and further study of the antigens and IC in the tissues were essential to elucidate the mechanism of the disease.The potent study, which can get more information of the antigens and IC about the human bodies with HFRS from the tissues of autopsy cases died of HFRS, was handicapped by the routine immunocytochemical methods which were unavailable for the detection of the antigens in HFRS autopsy tissues especially in the long-storage formalin-fixed paraffin-embedded tissues of patients died of HFRS.Recently, the problem was easily resolved, which should be attributed to the more sensitive immunocytochemical methods developed in our lab for a long time of efforts.In present paper, the antigen detection and antigenic analysis in the tissues by 15 clones of MAbs and PAb were performed on 16 kinds of 10%...