Mechanism Of Angiogenesis Inhibitor Generation

Angiogenesis, from pre-existing capillary sprouting new blood vessel, is a fundamental process in vivo, and it's also an important manner in keeping the stability and integrity of the body and maintaining the function of tissue or organism. Angiogenesis, as a multi-step process, is under strict control in vivo, which is carried out by a lot of paracrine factor of polypeptide. During each stage of angiogenesis, there are many different factors that take action synergically in temporal and spatial manner to the ongoing of vessel formation. Accorrding to their attribution to angiogenesis, these factors can be generally divided into positive and negative regulating factors. The balance between positive and negative regulation determines the switch of angiogenesis.Tumor is a kind of disease of malignant hyperplasia, characteristic of sustained and active angiogenesis. Many studies demonstrated that tumor growth and metastasis depend on angiogenesis. To get its acquired blood vessel supply, tumor can secret a lot of angiogenic factors. At the same time, some tumors were proved to be able to produce angiogenesis inhibitors, such as angiostatin and endostatin, which were derived from plasminogen and collagen XVIII respectively, two pre-existing protein in vivo.