Studies On The Chemical Constituents Of Eugenia Caryophyllata And Cimicifuga Foetida

This dissertation consists of three parts. In the first and the second parts, the chemical constituents from the flower buds of Eugenia caryophyllata and the rhizomes of Cimicifuga foetida were reported. The third part is a review on a structure-activity relationship of the cycloartane triterpenoid from Cimicifuga species.The first part is composed of two chapters. The chapter 1 is about the isolation and identification of the chemical constituents from the flower buds of E. caryophyllata. A new phenolic glucoside gallate, methyl 2-O-(6'-O-galloyl)-β-D- glucopyranosylbenzoate (24), together with thirty-three known compounds has been isolated from the ethanol extract of the flower buds of E. caryophyllata through repeated column chromatography on normal and reversed phase silica gel. The structure of the new compound was elucidated on the basis of spectral and chemical evidence. Those known compounds were belonged to flavone, triterpenoid, tannin and some simple compounds. Among them, 12 compounds were isolated from the title plant for the first time. The second chapter describes the capillary GC-MS analysis of the volatile components and the HPLC-MS/MS analysis of the polar constituents from the flower buds of E. caryophyllata, in order to detect the main constituents in the crude extract rapidly and precisely.The third chapter is about the chemical constituents of the rhizomes C. foetida, a traditional Chinese medicine which was used as anti-inflammatory, analgesic and antipyretic agents. Our investigation of the bioactivities constituents of the rhizomes of C. foetida led to the isolation of five new cycloartane triterpenoids, which were characterized as cimicidol-3-one (38), 3'-O-acetyl cimicifugoside H-1 (41), 2'-O-acetyl cimicifugoside H-1 (42), (3β,12β,16β)-12-acetoxy-16,23-epoxy-9,19- cyclolanost-22-ene-24-one 3-O-β-D-xylopyranoside (44) and cimicifugadine (54),...