Expression Change Group Ⅰ MGluRs In Rat MVN And Flocculus After Unilateral Labyrinthectomy And Expression Change Of AChR-M1 In Rat MVN After Unilateral Labyrinthectomy

Objective: To observe the expression change of Group I mGluRs in the medial vestibular nucleus(MVN) following left unilateral labyrinthectomy(UL). METHODS: After secting left labyrinthectomy, the change of Group I mGluRs was detected by Immunohistochemistry, In situ hybridization. RESULTS: Group I mGluR5 was induced increase in both side MVN after unilateral labyrinthectomy.By contrast, mGluR1 was induced decrease. However,that of the lesioned side was stronger than that of the unlesioned side. CONCLUSION: UL can induce change in the MVN,The fall in the resting discharge of the primary vestibular afferents and/or in thedeafferented central vestibular neurons may cause the change of mGluRs. But the significance of the change of mGluRs in the vestibular compensation is still un-known. Abstract Objective: Studies revealed that cerebellar flocculus-parafiocculus complex plays an importmant in vestibular compensation.To observe the expression change of Group I mGluRs in flocculus following left unilateral labyrinthectomy(UL). METHODS: After secting left labyrinthectomy, the change of Group I mGluRs was detectedby Western-blot and RT-PCR. RESULTS: Group I mGluR5 was induced increase in both side flocculus after unilateral labyrinthectomy.By contrast, mGluR1 was induced decrease. However,that of the lesioned side was stronger than that of the unlesionedside. CONCLUSION: UL can induce change in the MVN,The fall in the resting discharge of the primary vestibular afferents and/or in the deafferented central vestibular neurons may cause the change of mGluRs. But the significance of the change of mGluRs in the vestibular compensation is still un-known. Objective: To observe the expression change of Ml Muscarinic receptors in the medial vestibular nucleus(MVN) following left unilateral labyrinthectomy(UL). METHODS: After secting left labyrinthectomy, the change of Group I mGluRs was detected by Immunohistochemistry and Western. RESULTS: Ml was induced increase in both side MVN after unilateral labyrinthectomy. However,that of the lesioned side was stronger than that of the unlesionedside. CONCLUSION: UL can induce change of Ml in the MVN,The fall in the resting discharge of the primary vestibular afferents and/or in the deafferented central vestibular neurons may cause the change of M1. But the significance of the change of M1 in the vestibular compensation is still un-known.