Font Size: a A A

Studies On Pharmacological Constituents Of Shuanghuanglian Powder Injection

Posted on:2008-05-11Degree:DoctorType:Dissertation
Country:ChinaCandidate:B Q LvFull Text:PDF
Abstract/Summary:PDF Full Text Request
Shuanghuanglian (SHL) powder injection is the first freeze-dried powder injection of traditional Chinese medicine (TCM), which is made from Flos Lonicerae Japonicae, Radix Scutellariae and Fructus Forsythiae. It can eliminate heat, dispel toxins, evacuate wind and alleviate surface symptoms, so it has been widely used to treat fever, cough, throat pain and symptoms like these caused by infections to the pharynx and larynx, lungs and tonsil. Not only can it strengthen immunities, but also can resist virus and bacteria, so it has been one of the first choices of TCM to treat infectious diseases of the pharynx and larynx recently. In clinical, it has been applied widely and obtained satisfied results. With patients who were given this preparation increasing, more and more adverse drug reactions (ADRs) of SHL powder injection have been reported accordingly which mainly include skin's irritabilities, breathe toughly, blood vessel's edema, irritations of vein, muscle pains, dermatitis over whole body, palpitations, dizzy, nausea and vomit etc.. Studies on reasons of ADRs of SHL powder injection are focused on preparation, patient, usage and dose, dissolvants and co-use with other medicines etc.. Chlorogenic acid and baicalin are two main constituents and detected components of SHL powder injection, some reports say maybe this two constituents are ones of the reasons of ADRs of SHL powder injection. This research mainly included isolations and identifications of chemical constituents of SHL powder injection, and analyzed pharmacological relationships of constituents and SHL power injection to find out what its pharmacological constituents is. To manufacture SHL powder injection, isolate chemical constituents of it with reagents, column chromatograms and preparation high performance liquid chromatography (PHPLC), and then identify them with IR, 1HNMR, 13CNMR, physical and chemical characters. Finally, to compare these data with the documents reported, and then confirm these chemical compounds.20 chemical compounds have been isolated and identified in this research. They are glucose (Ⅰ), chrysophanol (Ⅱ), physcion (Ⅲ), isopimpinellin (Ⅳ), rengyol (Ⅴ), caffeic acid (Ⅵ), chlorogenic acid (Ⅶ),β-sitosterol (Ⅷ), oleanolic acid (Ⅸ), ursolic acid (Ⅹ), phillyrin (Ⅺ), baicalin (Ⅻ), rutin (ⅩⅢ), wogonoside (ⅩⅣ), hyperoside (ⅩⅤ), quercitrin (ⅩⅥ), luteolin (ⅩⅦ), quercetin (ⅩⅧ), baicalein (ⅩⅨ) and wogonin (ⅩⅩ). In these 20 chemical compounds, 13 of them were isolated and identified for the first time from SHL powder injection except caffeic acid (Ⅵ) ,, chlorogenic acid (Ⅶ), phillyrin (Ⅺ), baicalin (Ⅻ), wogonoside (ⅩⅣ), baicalein (ⅩⅨ) and wogonin (ⅩⅩ).Through sorting out the documents reported, we have summed up that most of the compounds have instinctive pharmacological activities. Anti-virus, anti-bacteria, inflammation-resistant and immunity regulations of SHL powder injection have close relationships with such chemical constituents as baicalein, baicalin, caffeic acid, chlorogenic acid, chrysophanol, physcion, 13 -sitosterol , rutin, hyperoside, luteolin, oleanolic acid and ursolic acid. These chemical constituents' pharmacological activities and their interactions may explain the pharmacology and ADRs of SHL powder injection to a certain extent.
Keywords/Search Tags:SHL powder injection, Chemical constituents, Isolation and identification, Pharmacological constituents
PDF Full Text Request
Related items