| Objective:To study the curative effect and function mechanism of southernwood and Dichroa febrifuga to resist premature beat, through clinical and experimental research. Methods:In clinical research, the curative effect of 160 cases of premature beat, together with the influence on the heart rate variability of 118 cases of extrasystole coronary heart disease were observed. In the experimental research, adopting the patch clamp techniques, study the effect of southernwood and Dichroa febrifuga on calcium and potassium ion channel in isolated myocytes of guinea pig.Results: About 160 patients of premature beat, the effective rate of general curative effects is 84.38%, while the total effective rate of the premature beat is 83.76%;Premature beats reduce significantly in Holter, from 335.26±329.31 times/24hours to 206.73±289.15 times/24hours(P<0.001);The effective rate of total clinical symptoms improved is 86.89%; The mild and moderate patients have efficiency respectively for 90.77%,85.71%. Have adjustive function on the cardiovascular autonomic nervous system: can reduce the average heart rate of 24 hours of the treatment group, and can evidently meliorate the cardiac autonomic nerve. The low concentration of Qingshan Mixture(1mg/ml and 10mg/ml) have no obvious effect on L-Ca, while that of 40mg/ml can distinctly restrain the L-type calcium current of acutely isolated ventricular mytocytes in guinea pig, but have unconspicuous effect on Iks current and its tail current Ikstail.Conclusion: (1) Southernwood and Dichroa febrifuga have the favorable curative effect to cure premature beat, (2) Southernwood and Dichroa febrifuga can restrain the L-Ca current, but have unconspicuous effect on Iks current and its tail current Ikstail.
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