| ObjectiveTo evaluate the efficacy and safety of simultaneous pancreas-kidney transplantation(SPKT) for treatment of insulin-dependent diabetes mellitus (IDDM) with uremia. Method: SPKT was performed on 2 uremic patients with diabetes mellitus. Bladder drainage was used for management of pancreas exocrine secretions. The patients were treated with ATG+FK506+MMF+Pred as immnosuppressive treatment. Results: The renal and pancreatic graft regained normal function. The serum creatinine, C-peptide and blood glucose decreased to normal levels 2 days after operation and supplementation insulin was completely stopped. One case had survived with normal grafts function for six yeays. No complications such as urinary infection and metabolic acidosis occurred. Conclusion: SPKT is an effective method for the treatment of IDDM with uremia.
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