| Background:Coronary heart disease (CHD) is importante disease for it has remained the leading cause of death in all over the world from one hundred years ago, and brings a huge burden of disease to family and society. Although age-adjusted cardiovascular death rates have declined in several developed countries in past decades, rates of cardiovascular disease have risen greatly in low-income and middle-income countries, with about 80% of the burden now occurring in these countries. There is a risen trend with the morbidity and mortality of CHD in China, and risk factors of CHD are working up.The morbidity and mortality of CHD is distinguishing in different geographic regions and among various ethnic groups. Some data suggest that risk factors for coronary heart disease vary between populations, regions and period. Even if the association of a risk factor with coronary heart disease is similar across populations, prevalence of this factor might vary, resulting in different population attributable risks (PAR). Hypercholesterolaemia is a independent risk factor of coronary heart disease. HDL is one of the most reliable negative risk factors for CHD, that mainly due to the role of HDL in reverse cholesterol reansport (RCT). ABCA1 and CETP are important protein in the RCT pathway, and their genovariation can promote or reduce the morbidity and prevalence by affecting the level and function of HDL.There is so high morbidity of CHD in Xinjiang, to learn the tendency of prevalence of CHD and diversity of risk factors provides evidence for prevention disease. It is a new way to prevent atherosclerosis on studying the risk factors with CHD and association of ABCA1 gene and CETP gene polymorphisms in races of the Uygur and Hans in Xinjiang. Partâ… Analysis on inpatient acut myocardial infarction surveillance in one hospital from 1996 to 2005Objectives:To learn the tendency of inpatients grewing and diversity of risk factors of CHD in year 1996 to year 2005 in a single hospital, and investigate the difference between the Uygur and Hans. Methods:In this retrospective analysis, data form patients with discharge diagnosis as acut myocardial infarction (AMI) from Jan.1996 to Dec.2005 were collected.1189 cases were retrieved and 1004 cases were analyzed in fine including 853 male and 151 female. In these cases, there were 697 Han,218 Uygur and 89 others races. To analyze the constituent ratio and case fatality rate of AMI inpatients, and to to compare the levels of risk factors from 1996 to 2005 between the Uygur and Hans. Results:(1) Both total inpatient number and patients with AMI increased year by year during the last 10 years in our hospital. The constituent ratio of AMI in hospital demonstrated the same increase. The ratio of inhospital patients with AMI was significantly higher in 2002-2005 than that in 1996-2001 (P<0.0001); (2) The case fatality rate of AMI inhopital descented year by year during the last 10 years. The case fatality rate reduced from 11.6% in 1996-2001 to 7.45% in 2002-2005; (3) The mean age of Uygur was more younger than Han's (P<0.05), and the mean age of male and female were significantly difference in Han (P<0.05). The mean age of male and female were not difference in Uygur. The proportion of male, case fatality rate, smoking and alcohol consumption status, the history of MI and stroke before, The proportion of complicating with hypertensive, diabetes and dyslipidemia was not difference between Uygur and Han. The level of TC and Lpa in Uygur was higher than that in Han (P<0.05); (4) The proportion of complicating with dyslipidemia was high. The elevated triglyceride levels and depressed high-density lipoprotein cholesterol levels were the primary dyslipidemia; (5) The levels of risk factors between Uygur and Han were not variance during the last 10 years in our hospital.Partâ…¡Study on the association of ABCA1 gene polymorphism with coronary heart disease in Uygur and HanObjectives:To investigate the association between ATP-binding cassette transporter A1 (ABCA1) gene polymorphism and coronary heart disease in Xinjiang Uygur and Han, as well as the differencs of genotypes and alleics distribution between Uygur and Han. Methods:Study participants were recruited from the department of cardiology, first affilianted hospital, Xinjiang medical university.358 unrelated CHD cases and 160 CHD-free control were recruited. The cases group included 180 Uygur patients consisting of 157 male and 23 female, and 178 Han patients consisting of 139 male and 39female. The control group included 65 Uygur individuals consisting of 44 male and 21 female, and 95 Han individuls consisting of 49 male and 49 female. Structured questionnaires were administered and physical examinations were undertaken in the same manner in cased and controls. Information about smoking, alcohol consumption, personal and family history of caediovascular disease, and history of hypertension, diabetes mellitus, myocardial infarction and stroke was obtained. To assay the levels of blood plasma total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B, lipoprotein a and blood glucose. To extract leukocyte genomic DNA and determine the ABCA1 genotypes by PCR-restriction fragment length polymorphism and Primer restriction analysis-PCR techniques, respectively in cases and controls. To analysis the differencs of genotypes and alleics distribution between cases and controls, as well as the differences between Uygur and Han. Results For ABCA1 gene: (1) The genotype frequency distribution and the frequency of allele for R219K polymorphism were not significantly difference between Uygur and Han; (2) The genotype frequency distribution and the frequency of allele for M883I polymorphism were significantly difference between Uygur and Han(P<0.01); (3) The frequency distribution of genotype and allele for R219K and M883I polymorphism were not significantly difference between cases and controls in two races; There was mild linkage disequilibrium between R219K and M883I polymorphism in toltal subjects beween Uygur and Han (D' <0.80); (4) The levels of blood fat in differet genotypes of R219K and M883I polymorphism were not significantly difference between Uygur and Han.Partâ…¢Study on the association of CETP gene polymorphism with coronary heart disease in Uygur and HanObjectives To investigate the association between cholesteryl ester transfer protein (CETP) gene polymorphism and coronary heart disease in Xinjiang Uygur and Han, as well as the differencs of genotypes and alleics distribution between Uygur and Han. Methods Study participants were recruited from the department of cardiology, first affilianted hospital, Xinjiang medical university.358 unrelated CHD cases and 160 CHD-free control were recruited. The cases group included 180 Uygur patients consisting of 157 male and 23 female, and 178 Han patients consisting of 139 male and 39female. The control group included 65 Uygur individuals consisting of 44 male and 21 female, and 95 Han individuls consisting of 49 male and 49 female. Structured questionnaires were administered and physical examinations were undertaken in the same manner in cased and controls. Information about smoking, alcohol consumption, personal and family history of caediovascular disease, and history of hypertension, diabetes mellitus, myocardial infarction and stroke was obtained. To assay the levels of blood plasma total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B, lipoprotein a and blood glucose. To extract leukocyte genomic DNA and determine the CETP genotypes by PCR-restriction fragment length polymorphism and Primer restriction analysis-PCR techniques, respectively in cases and controls. To analysis the differencs of genotypes and alleics distribution between cases and controls, as well as the differences between Uygur and Han. Results For CETP gene:(1) The genotype frequency distribution and the frequency of allele for-629A/C polymorphism were not significantly difference between Uygur and Han; (2)The frequency distribution of genotype and allele for Taq I B and-629A/C polymorphism were not significantly difference between cases and controls in two races; There was strong linkage disequilibrium between Taq I B and-629A/C polymorphism in toltal subjects beween Uygur and Han(D'>0.80); (3)In case group of Han, the level of apoA in B1B1 genotype of Taq I B polymorphism were markedly higher than those in B1B2 and B2B2 genotype (P<0.05); In control group of Han, the levels of TQ LHL-C, HDL-C and apoA were gradually raised with the increasing of B2 allele, and the levels of above lipoprotein in B1B1 genotype of Taq I B polymorphism were markedly higher than those in B1B2 and B2B2 genotype (P<0.05); In control group of Han, the levels of TG, LHL-C, HDL-C and apoA were gradually raised with the increasing of A allele of-629A/C polymorphism, and the levels of above lipoprotein in AA genotype were markedly higher than those in AC and CC genotype (P<0.05); In Uygur, The levels of blood fat in different genotypes of Taq I B and-629A/C polymorphism were not significantly difference.Conclutions:(1) The inpatients with AMI increased year by year during the last 10 years in our hospital, especially in 2002-2005 there was significantly higher than 1996-2001; The case fatality rate of AMI inhopital tended to reduse during the last 10 years; The proportion of complicating with dyslipidemia was high, and the elevated triglyceride levels and depressed high-density lipoprotein cholesterol levels were the primary dyslipidemia; The levels of risk factors between Uygur and Han were not variance during the last 10 years in our hospital.(2) The genotype frequency distribution and the frequency of allele for M883I polymorphism of ABCA1 gene were significantly difference between Uygur and Han; There was not correlation between R219K and M883I polymorphism of the ABCA1 gene and coronary heart disease in Uygur and Han.(3)Taq I B and-629A/C polymorphism of CETP gene had good infaction on metabolism of lipoprotein in Han; There was not correlation between Taq I B and-629 A/C polymorphism of the CETP gene, and coronary heart disease in Uygur and Han.
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