| [Objective]Using retrospective and forward-looking epidemiological survey clinical research methods, summarized in locally advanced non-small cell lung cancer with chemotherapy combined traditional Chinese medicine (TCM group) and individual use of radiotherapy and chemotherapy (TC group) and clinical data of two forms of treatment, observation of patients clinical efficacy, survival, quality of life, immune function, toxicity and so on. Of Integrative Medicine at relieving symptoms, preventing recurrence, improve quality of life and prolong survival aspects of the efficacy advantages. To provide more clinically effective, more economical, more reliable method of treatment.[Methods]1 Radiotherapy:Using 3DCRT and linear accelerator to treat, before treatment, CT simulation location firstly. Utilizing body coating or Vacuum sack to moulding and fix. Positioning in skin, resetting marker,. CT contrast enhanced scan, slice thickness of scanning are.3～5mm. Physician and physics doctor design treatment planning. Determining target volume (PTV,CTV,GTV) and outlining the contours of the tumor and risk organ in common. The implementation of three-dimensional reconstruction. To aim directly at tumor position design 3-5 irradiation fields. Using 90% isodose curve to cover tumor edge. Using BEV and DVH for evaluation and Optimization of treatment plans. Lead produce the overall model of the implementation of conformal radiotherapy. Fractionated irradiation 6mV-X,2～3Gy/f, 1f/d,5f/w,4～5w. Changing the radiation angle and using non-coplanar irradiation to control V20≤30%,≤40Gy spinal cord volume control and GTV dose ultimately 60～70Gy.2 Chemotherapy:Single-agent chemotherapy with paclitaxel,1 day before irradiation, that is given paclitaxel chemotherapy every Sunday, dose:60mg/m2, continuous intravenous infusion of 3 hours,1 time/week for 4 to 5 weeks.3 The traditional Chinese medicine:Matrine injection 30ml to 250ml 90% sodium chloride solution intravenously 1 time/day,21 day cycle, repeated after 3 weeks rest.4 Observation index:①recent indicators of clinical remission rate, response rate (according to WHO solid tumor evaluation standard);②clinical long-term indicators 1,2,3 year survival rates, median survival;③before and after treatment quality of life (Karnofsky score), Hemoglobin levels, anemia, weight changes, pain conditions;④case of immune function before and after treatment;⑤side effects of radiotherapy and chemotherapy.5 Data management and statistical analysis:Use SPSS 17.0 Software.[Results]1 Clinical Comparison of the two groups:Comparative efficacy of two groups. TC group the total effective rate 71.69%; TCM group, the total effective rate 83.01%, the difference was not significant (P>0.05); disappearance rate between the mass and the disappearance rate of mediastinal lymph node,no significant difference between the two groups of treatment. In the long-term efficacy of the treatment groups compared, TC group, median survival 14 months, 1-year survival rate 66%,2-year survival rate of 24.5%,3-year survival rate 9.4%; TCM group, median survival 18 months,1-year survival rate 71.7%,2-year survival rate 41.5%,3-year survival rate 16.9%, difference between two groups was significant (P<0.05), that in the long-term-efficacy in the TCM group is better than TC group treatment,2 Groups to improve the quality of life compared to the situation:Two groups of patients before and after the change in KPS score, the difference was significant (P<0.05). Description of TCM.group KPS score after treatment group of patients the overall increase. Two pain conditions, the difference was significant (P<0.05). TCM group of patients that pain after treatment than TC group improved significantly. Two groups of. patients body weight changes, the difference was not significant (P>0.05). Anemia compared two groups:no significant difference (P>0.05). Chinese medicine in treatment can improve immunity.3 Comparison of two groups of immune function:The two groups before treatment, T lymphocytes and natural killer cells by NK paired t test level, the differences were not statistically significant (P>0.05), after treatment, T lymphocytes and natural killer cells by the level of NK After paired t test, the difference was statistically significant (P<0.01). Changes in serum Ig levels, two groups of patients before treatment, there was no significant difference (P>0.05), comparable before treatment. After treatment, serum IgG, IgA and IgM, the difference was statistically significant (P<0.05). Description of the immune function of patients with TCM group was significantly better than TC group of patients.4 Comparison of two groups of adverse reaction:Two cases of acute radiation esophagitis, the difference was not significant (P>0.05). Two cases of acute radiation pneumonia, the difference was not significant (P>0.05). Two groups of patients decreased after the WBC, the difference was significant (P<0.05). Chinese medicine treatment can reduce the toxicity of radiotherapy and chemotherapy.[Conclusion]The research showed that Compound Kusheng injection can improve the clinical benefit rate, can inhibit tumor progression, the efficacy of consolidation chemotherapy and radiotherapy, can significantly relieve pain and improve the KPS, to reduce hematologic toxicity, improve quality of life and enhance chemotherapy and radiotherapy in patients with tolerance, locally advanced lung cancer can be used as an ideal adjuvant should be widely applied.
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