| Virus B hepatitis is the second legal contagious disease. It has the characters as stong infectivity, complex route of infection, wide prevalence and high morbility; There is very high morbility country.The positive rate of HbeAg is about ten percent and latent infection is universal.The symptoms of the HBV infection is coraplex.It can result in acute hepatitis, chronic hepatitis, liver cirrhosis, liver carcinoma. It also can cause death in serious case. So it can harm people's health greatly.The pathogenic mechanism of virus B hepatitis is very complex. So far it can't he understood well. But it is generally accepted that HBV isn't the main direct reason of the damage of liver. The damage of liver is reduced by immunopathologic mechanism.That is the liver cytotoxic mechanism resulted by ADCC reaction that is mediated by Tc cell and anti-LSP. At present there stil 1isn't effective method to euro chronic virus B hepatitis using westernmedicine. It is only in the clinic trial to find anti-virus medicine and cure it by immunoregulation.The curative effect isn't definite.Virus B hepatitis is defineted as "jaundice" "hypochondriac pain", "stagnation of liver qi" in TCM according it's symptoms. It's basic mechanism is deficiency in orgin and excess in superficiality.It is to say the fundamental is the deficiency of qi and yin of liver, kidney and spleen while the superficiality is damp-heat, stagnation of qi and blood stasis. So effective result may be reached by using the method of "strengthening the body's resistance to eliminate pathogenic factors".Xiao Chai Hu Tang is the main formula to cure diseases in Shaoyang channels in Treatise on Fobri le Diseases. The mechanism of diseases in Shaoyang channels 3 is "the deficiency of qi and blood and the opening of striae of skin result in the entry of pathogen to struggle with the body's resistance and stop in hypochondiuro. It's symptoms are alternate attacks of chill and fever, feeling of fullness and discomfort in chest and hypochondrium anorexia, vexation and vomition, diarrhea, fullness and rigidity of hypochondrium, all kinds of jaundices and so on. So it can be said that the function of Xiao Chai Hu Tang is to strengthen the body's resistance to eliminate the pathogenic factors. It was used to cure chronic virus B hepatitis in recent years and had active result.Modified Xiao Chai Hu Tang is a formula made by professor Xiong Manqi on the basis of Xiao Chai Hu Tang. Astragalus root, red peony root, red sage root is added according to the clinic characters of virus B hepatitis and individual experiences. This formula is better at strengthening the body's resistance and eliminate the pathogenic factors. The curative effect is very good using this formula to cure chronic virus B hepatitis. In this study, the curative effect on chronic virus B hepatitis and the reasonability of formation were furtherly tested by clinic and experimental researches in order to find a safe and effective formula of TCM for chronic virus B hepatitis.The results of the experiments:1. Three different groups of herbs in Modified Xiao Chai Hu Tang can inhibit HbsAg and HbeAg in vitro. But the effect of the whole formula is more outstanding.2. The whole formula is more effective than half of the formula and simple herb in vivo. It's effect is more lasting than that of ACV. And the returning of virus wasn't found. 4 3. The function of the whole formula on improving of liver pathogenesis is more obvirous than that of half of the formula and simple herb.It can be thought that Modified Xiao Chai Hu Tang can cure the chronic virus B hepatitis and the formative principal of the formula has experimental basis.The results of the clinic research:l.The Modified Xiao Chai Hu Tang can apparently improve the symptoms of the patients with chronic virus B hepatitis.2. It can reverse the signs of HBV.3. 11 can apparently improve... |
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