Artery Hepatic Tumor In Situ Inactivation Experiments And Clinical Studies

Objective: to investigate the possibility and practicality of liver segmental ablation (LSA) technique via transarterial route. Materials and Methods: 18 New Zealand white rabbits weighted from 2.2 to 2.7kg were selected and divided into three groups at random. All the right femoral artery were cannulated surgically for the placement of 4F catheter introducer sheath, and the branches of the right and left hepatic artery were entered with coaxial microcatheter technique in 7 and 11 rabbits. The tissue ablation agent (TAA) was infused into the microcatheter at the rate of 0.1 milliliter per second as the TAA was seen to enter hepatic artery, arteriole, and portal venule until the liver segmental stain and portal vein revealed. All the vital signs was monitored intra-operatively and blood specimens were collected at 0, 1, 3, 5, and 7 days after LSA for the hepatic, renal function, and blood routine tests. Results: Pathological assay showed that liver segment ablated with TAA was coagulatively necrotic either grossly or microscopically 1~2 weeks after LSA. The hepatic, renal function, and blood routine returned to normal in all animals7 days later. Conclusion: Liver segmental ablation technique is a safe, practical and effective alternative to local surgical hepatectomy.