| This dissertation reviewed documents of research of erectile dysfunction(ED) by the numbers on such aspects as epidemiology, headstream of Traditional hinese Medicine (TCM) and west medicine, regulation and control of ED,relation between the theory of NO with regulation and control of ED. The paper lso reviewed the differentiation and syndrome patterns of TCM, patent rescriptions and particular drugs and gene therapy. It is shown that the traditional principle of treating ED of TCM is tonifying kidney. Based on the study,concluded experience and academic idea of Pro. Xu Fusong for treating ED, the paper put forward the system of brain - essence- testicle (ovary); strengthened therapeutic principle of tracing the source according to the symptoms and treating ED according to reasons; also encouraged the treatment of combination between syndrome differentiation and disease discrimination . The paper regarded that treating primary change when the disease is at chronic stage, and tonifying kidney yin is the primary principle. It is shown that attaching importance to treat body and mind simultaneously and integrative regulation principle. Objective of clinical study: to observe the effect ofEr Di Bie Jia Jian on ED;to explore the mechanism of tonifying kidney yin on regulating brain-essence-testicle (ovary) system. Method: 60 patients with ED were randomly divided intotwo groups: treating group (30 cases) treated by Er Di Bie Jia Jian and controlgroup (30 cases) treated by Zhuang Yang Fu Chun Ling. The observational itemsare the clinical effect or the scores of kidney deficiency syndrome before andafter treatment, serum hormones, NPT check and the result of mental scale test.Result: treating group had better effect than control group (P<0.05). Regarding to aching and softness of loin and knees, tinnitus and declined memory of kidneydeficiency symptoms, the changing of scores before and after treatment in treating group were significantly better than those in control group (P<0.05). Comparing the two groups, every serum hormones changing after treatment of treating group were significantly better than those of control group(P<0.05). The scores about confidence of erection of both groups were increased significantly (P<0.05). Kidney deficiency had inverse correlation with the NPT check (P<0.01). In MMPI test, compared ED group with normal group, the scores of Hs, D, Pt and Si scales had significantly difference. And the index for depression of ED group were significantly higher than normal group(P<0.05). Conclusion: therapy of tonifying kidney yin had better effect on ED than that of strengthening yang. In addition,tonifying kidney yin therapy had longer lasting effect. Tonifying kidney yin had whole regulating and treating action by regulating hypothalamus-pituitary-testicle axis Ojective of experimental study: to explore the mechanism of Er Di Bie JiaJian's multitarget integrative regulation, taking interstitial cell of testicleand male hormones as the link, the study combined local study with whole study. Method:making the rat model of kidney deficiency induced by glucocorticoid action, to observe male hormonoid activity, influence on latency of penis erection and the weight of relative organs. In addition, to study interstitial cell of testicle on cell biological level by microscope and electron microscope observing. Result:compared group treated by Er Di Bie Jia Jian with group of kidney deficiency,rats weights were significantly increased (P<0.05), automatic movement increasedsignificantly (P<0.01), latency of penis erection became significantly shorter(P<0.01), weights of attached sexual organs and testicle were significantly higher after treatment(P<0.05), level of testosterone increased significantly (P<0.05), weights of hypothalamus, pituitary and thymus were significantly increased (P<0.05). It is suggested under electron microscope that Er Di Bie Jia Jian improved pathological changes of testicle interstitial cells .Conclusion: Er Di Bie J... |
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