Analysis And Observation On The Effect Of Yougui Capsules In The Elderly Male Patients With Kidney Yang Deficiency On Hypothalamus Pituitary Thyroid Axis Function

Purpose: this topic in kidney Yang deficiency syndrome and the hypothalamus-pituitary-thyroid axis relationship on the basis of selection of different degree of kidney Yang deficiency of elderly male patients, divided into light, medium, heavy three groups, after taking right owned by capsules on thyroid hormone(FT3, FT4, TSH) levels and changes of clinical symptoms and signs of traditional Chinese medicine, reveal the rule of three groups of hormone level changes before and after treatment in patients with kidney Yang deficiency and the correlation between integral and hormone level changes, and to explore the right return capsule of elderly male patients with kidney Yang deficiency of thyroid axis function.In order to improve the health status of elderly male patients and slow down the ageing process to provide certain theoretical basis and feasible ideas and methods.Methods: according to the 1986 edition of deficiency syndrome differentiation of TCM reference standards and yan stone forest the kidney Yang deficiency syndrome differentiation factor score rules determine the degree of kidney Yang deficiency, and develop into and exclusion criteria, selection of March 01, 2014 to January 30, 2015 in the first affiliated hospital of shandong university of TCM health, 90 patients in hospital were divided into light, medium, heavy three groups, have three groups of patients limit high iodine diet, more modern, comfortable, work were performed on the basis of the right to return capsule oral treatment, for eight weeks.Dawn extraction in patients with peripheral venous blood, on an empty stomach by radioimmunity method, respectively, were observed before and after treatment of kidney Yang deficiency syndrome integral, and thyroid hormone(FT3, FT4, TSH) the change of the index, such as level of all data using SPSS17.0 statistical software for processing analysis, measurement data using ` x + s, comparison in the group by t test and compared using analysis of variance between groups.If P < 0.05 was statistically significant;If P < 0.01, said there are significant differences.Results:1.The influence of the return capsule of TCM symptoms: Compare of kidney Yang deficiency symptom score before and after treatment in three groups were P < 0.01;By the spearman rank correlation analysis, three groups of TCM symptoms outcome comparison results before and after treatment, P = 0.004(P < 0.05), it is concluded that the degree of kidney Yang deficiency and kidney Yang deficiency symptom score there is a low negative correlation relationship between curative effect level.That after treatment with right return capsule, of three groups of patients with kidney Yang deficiency symptoms were improved, and the heavier degree of kidney Yang deficiency, TCM symptoms improved after medication, the more obvious.2. Right to return capsule on the influence of thyroid hormone levels: to observe the light, medium and heavy three groups of patients before treatment, found that as the degree of kidney Yang deficiency is aggravating, FT3, FT4 and TSH levels are declining.Three groups of patients after treatment with right return capsule, FT3, FT4, TSH levels tend to rise, the lighter and degree of kidney Yang deficiency, FT3, FT4, TSH level changes after medication, the more obvious.3. Relevance: kidney Yang deficiency symptom score before treatment and FT3, FT4, TSH are a highly negative correlation, the more severe the kidney Yang deficiency, the lower thyroid hormone levels;Thyroid hormone is closely relative to both between the two, namely, FT3, FT4, TSH has a tendency to higher or lower at the same time.Age are positive correlated with kidney Yang deficiency symptom score, which increases with age, kidney Yang deficiency degree aggravating gradually;Age are negatively correlated with FT3, FT4, TSH.Conclusion:As the degree of kidney Yang deficiency is aggravating, thyroid hormone(FT3, FT4, TSH) were gradually reduced.After treatment with right return capsule, light, medium and heavy of three groups of patients with kidney Yang deficiency symptoms and signs improved and thyroid hormone levels were elevated;The heavier and degree of kidney Yang deficiency, kidney Yang deficiency symptom score, the more obvious change, but the less thyroid hormone level changes.Kidney Yang deficiency symptom score before treatment and FT3, FT4, TSH are a highly negative correlation, the degree of kidney Yang deficiency is heavier, FT3, FT4, TSH level is lower, can infer that degree of kidney Yang deficiency and pituitary- thyroid axis function shows negative correlation;FT3 and FT4, FT4 and TSH, FT3 and TSH were positively related, namely, FT3, FT4, TSH has a tendency to higher or lower at the same time.Age are positive correlated with kidney Yang deficiency symptom score, age, the more serious the degree of kidney Yang deficiency;Age are negatively correlated with FT3, FT4, TSH.To sum up, as the degree of kidney Yang deficiency is aggravating, right the influence of the return capsule of pituitary- thyroid axis function is not obvious.