| Background: Chronic Heart Failure is a clinical familiar and frequently occurring disease, which of incidence of the disease appears the up-trend in the last few years. The domestic and international research has discovered that the Renin-Rngiotensin System of Sympathetic Nervous System is activated excessively in advanced people who have Chronic Heart Failure. The main activity of the system of RAS is the Ang , the contraction of afferent, the secretions of ALD, the release of CA and the promotion of the smooth myocyte that grow hyperplasic of the rho factor, all of these functions depend on the function of AT1.The combination of Ang receptor and AT1 passes the IP3 inside the cell and the DAG path, then activate the PKC and the activated PKC make essential transcriptional factors in some proteinase phosphatase turned; Since these activated transcriptional factors working with DNA, new contraction proteinase growth rho factors and growth rho factor receptors are synthesized. The result is that myocardium turn fatty and thick, lead to the heart failure.The Ang receptors and its signal conducts are playing an increasingly important role in the pathogenesis of the Chronic Heart Failure and remodeling in ventricle. The Ang receptor antagonism elixir and ACEI medicine develop the clinical treatment in affirmative CHF function by ameliorating the remodeling in ventricle; Blockading or antagonizing RAS system's activity can cure the heart failure or improve the prophylaxis of the heart failure. The blockade Ang receptor benefits to alleviate remodeling in ventricle, increasing the vascular accommodation, lowering the ventricles pressure, decelerating the CHF development, increasing living quantity, lowering the CHF death rate. Repressing the RAS system', especially the Ang ',function to the cardiac is the key to cure the heart failure.The clinical research discovery that qi-deficiency and blood-stasis leads to 85% of Chronic Heart Failure, which is the main pathological mechanism of CHF. Though many researches report a traditional Chinese drug compound recipe, particularly the compound prescribes with the function of replenishing qi and activating blood, can improve the curative effect obviously, but in deed we know little about the mechanism about this kind of treatment Especially there are no reports about the relations among qi-deficiency and blood-stasis syndrome of CHF, Ang , Ang receptor-AT1 and the effect of compound prescribe with the function of replenishing qi and activating blood in Domestic and International Cultural heritage.Purpose: This research bases on the certain benefit foundation of the clinical effect in the treatment of CHF with QiangXinTongMai tiny pill, emphasizes on the Ang receptor and its signal conduct; It studies the variety of the Ang , PRA, TXB2, PA I - I in serum, and the expression of AT1 -mRNA to the Chronic Heart Failure and the influence of the Ang , PKC in myocardial organizes; It announces to public the function mechanism of the Traditional Chinese medicine cure CHF. Method: The clinical research: With 90 CHF patients for object, they are divided to 60 examplesnamed model group and 30 examples named control group at random. Experiment group use a day of QiangXinTongMai tiny pill to take orally three times under the normal regulations treatment, and western medicine group use Losartan 50mg once a day orally under the normal regulations treatment. We observe eight weeks, prognosticate the curative effect of the two groups, general condition, poison side effect and measure improvement circumstance of the heart function by color Doppler pleasure hemodynamic by BV-100 bloods glue instrument which made by TaiRuoDe in Peking, examine Ang by the radioimmunoassay.The experiment studying: 100 Wistar Big rat, male, are divided into 5 groups at random: normal group, model group, losartan group in western medicine, group in large dosage of traditional Chinese medicine and group in middle dosage of traditional Chinese medicine. We can get the animal model of myocardial infarctio...
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