| Main symptoms of osteoarthosis of knee (KOA) were pain in knee and difficulty in movement. Such patients, varied from young to old had greatly difficulty in movement, moving in pain and affecting their quality of life. Due to the cause and development of the illness had not unveiled totally; there is lack of efficient remedial at present stage. Through the experience from western medical and traditional Chinese medical on KOA, with the knowledge from revision of past traditional Chinese medical research reports, on the basis of classification of KOA into traditional Chinese medical illness development, remedial method, prescription of herbs, together with traditional Chinese medicine theory of " Kidney function Bone, Liver function Tendon, Stomach meridian of Yang Ming controls all bone and tendons, and smoothen joints" and development of KOA with Singapore's characteristic of illness development pointed out that main types of traditional Chinese medical symptoms in Singapore's KOA and its illness development theory of " Over-exhausted, Dysfunctions of Liver and Kidney, gather heat in Stomach meridian of Yang Ming, dysfunction caused by Wind and Wetness, under-nutrition of Bone and Tendons", simultaneously with the inspiration of remedial, using mainly " Nutrition of Kidney and Liver, Clearing of gather heat in Stomach meridian of Yang Ming", selectively with " Removal of Wind and Wetness" or " Smoothened meridians"; under such positive influences, Yu Nü Jian formula decoction and its efficiency as evidence, using Yu Nü Jian together with additional herbs as remedial under clinical observation for its effectiveness on KOA. Our research programme was divided into two sections: Investigation on its traditional Chinese medical theory and its experience for Yu Nü Jian formula used as prescription for KOA, and clinical research for Yu Nü Jian formula with additional herbs used as prescription for KOA. Investigation on its traditional Chinese medical theory and its experience for Yu Nü Jian formula used as prescription for osteoarthosis of knee (KOA) From the term 'osteoarthosis of knee (KOA)', analyzing its symptoms and illness development similar to the past traditional Chinese medical theory shows that KOA belong to 'Bi' and 'Wei' symptom, which both include the 'over-exhausted of Bone and Tendon' and 'dysfunction of Liver and Kidney ' as development of illness, but their different where the early stage of 'bi', caused by external factors; during the development of the KOA, external factor causing the main symptoms and changes, where it is different from the development of 'Wei' symptoms which cause by dysfunction of inner organs. From the past experience, it is found that this illness is caused by 'dysfunction of Liver and Kidney, further damage by external factors and blockage at meridian'; given the environment in Singapore, eating habits and lifestyle, compare to China, the symptoms mainly 'shortage of yin element and gather heat and blockage in meridian' which shown the development of illness in Singapore :'Inadequate functioning of Liver and Kidney, gather Heat in Stomach meridian of Yang Ming', further damage by external factors. According traditional Chinese medical theory, Yu Nü Jian formula shows capability of resolving the cause of the illness and worth dissemination in conservative therapies. Clinical research on Yu Nü Jian formula with additional herbs on KOA Based from past experience and comparison method, theoretically clinical research will be using Yu Nü Jian formula as remedial for KOA . Traditional Chinese medical diagnosing specialties, symptoms on knee, pain in KOA as main symptom and traditional Chinese medical symptoms, together with other symptoms beside symptoms found on knee, considering its comprehensive efficacy, effectiveness on knee and other symptoms etc, a comprehensive analysis, assessment and observation done at different stages of prescription and its functions analysis were taken in consideration of clinical design, in order to show...
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