| Object:1.To build up structurally clinic informational gathering system of diabetes mellitus , achieving a new thought of intergrative on clinic and scientific research .2To testify the limitation of sanxiao differentiation,and to prove the objectivity and practicability of three-typed differentiation by mining data from the gathered DM cases.3.To probe into the medical herbs on DM and its complications of the heart,the brain and the kidney by mining data from the treatment of DM with three-typed differentiation of symptoms and signs and to testify its instructive significance for clinic. Method:1.Based on C/S systemical structure,with software of power builder and visual basic language,we exploited and designed the structural module of system of DM,clinic informational gathering.Referring to the criterion for case history writing issued by State Administration of Traditional Chinese Medicine, we exploited and designed the interface of the gathering system; with the guiding rule on new Chinese traditional medicine issued by the ministry of health , the study of DM of the Integration of Traditionnal and Western Medition, The No.6.edition textbook of diagnostics of traditional Chinese medicine, The No.5 edition textbook of diagnostics of western medicine ,et al. Combined with the study and analysis of case history in hospital.establish structural field of interface of structural DM clinic informational gathering system and structural degree.2.By applying the SAS8.2 software, we progressed the main data mine about describing stat. and conjunctional analysis,Adopting X2 test to the count data.3.studying on 533 T2-DM paitients' frequencies of symptoms, frequency of sanxiao symptoms, common symptom flocks, the clinic value of sanxiao and three-typed Differentiation of symptoms and signs.4.refering to the criterion of national manifestations of differentiation of syndromes, principle of three-typed differentiation, professional committee of xiaoke disease .China Association of Traditional Chinese Medicine and Pharmacy, and the guiding rule on new Chinese traditional medicine issued by the ministry of health.Out of we summed up the differentiation types of DM,by distringuishing and analysis.we had conformed the differentiation types of DM to study the objectivity and practicability of three-typed Differentiation.5.Filtering the cases out of the 533 type-2-DM-cases we had gathered,ones with Chinese herbs used before with better clinic curative effect or recovery,we got 463cases,brought into the study the therapy of DM.Make statistics the frequency of medication in common use ,i.e.study pair Chinese herb.ternary Chinese herbs,quaternional Chinese herbs, andcommonly used prescription of Chinese materia medica in clinic, then comformed the clinic guiding significance of three-typed differentiation.Result:l.Set up structurally clinic informational gathering system of diabetes mellitus sucessfully,which it could suffice the requirement of noting case history by clinician,enhancing working effience and quality;storaging clinic datum information of diabetes mellitus simultaneously,sufficing requirement of dating mine.2.studying result of symptom in2-type diabetes mellitus and flock of symptom (1) Weakness was the tiptop of frequence among 2T-DM cases,473 cases,account for 88.74%,No.lsymptom of DM.cases of thirst and pleased drink was 303,account for 56.85%.diuresis^s cases was 106, account for 18.9%. cases of polyphagia and hungry was 77, account for 14.45%.Tongue quality of cases mainly appeared dull,red,weak,account for gore, hot ,weak mainly, fur character mainly appeared thin pale fur,yellow greasy fur.From the table of pulse manifestation,sufferervs pulse manifestation were very dispersely,showing pulse manifestation were difference in individual abviously.deep and thready pulse was the tiptop, showing that DM appear syndrome of qi deficiency and syndrome of yin deficiency.(2)Liking drink, polyphagous and hungry .diuresis, which were samxiaos classicial symptoms ,their frequence was 28 cases ,account for 2.25%(3)The mostly symptoms associated with with thirst and pleased drink show as follow: weakness,eye blur,swirl,limb numbness,thin fur. The mostly symptoms associated with with polyphagous and hungry show as follow:thist and liking to drink, frequent micturition ,weakness,thin fur; The mostly symptoms associated with diuresis show as follow: thirst and pleased drink, eye blur, frequent micturition, thin fur,weakness.Those facts show there are many other symptoms among the classic symptoms of sanxiao of all cases.(4)Among the cases,which show thirst and pleased drink,some cases appear diuresis, polyphagous and hungry synchronously,accounting for 32.23%. Among the cases.which show polyphagous and hungry,some cases appear thirst and pleased drink ,diuresis at the same titne,accounting for 35.37%. Among the cases,which show diuresis, some cases appear thirst and pleased drink polyphagous and hungry instantaneously, accounting for 26.46%.Those facts show there are other symptoms of liangxiao among a certain classic symptoms of xiao of cases,so it may cause warp diagnosis by shangxiao ,zhongxiao or xiaxiao only.(5)There are common flock of symptoms among the assembled tongue and pulse commonly:?Thin deep pulse and thin white fur(73cases):weakness account for 66 cases(90.4%),thirst and pleased drink account for 40 cases(54.8%),visual mistiness account for 32 cases(43.8%),swirl account for 30cases (41.1%),limb numbness account for 25 cases (34.2%),insomnia account for 21 cases (28.8%); constipation account for 20 cases(27.4%); inappetency account for 18 cases(24.7%).Thirst and pleased drink attended by weakness account for 35 cases (47.5%);visual mistiness and thirst and pleased drink,attended by weakness account for 16 cases(21.9%)?There are 73 cases which have thin white fur and dull red tonguexases of weakness were 66(90.4%), cases of thirst and pleased drink were 38(52%), cases of visual mistiness were 31(42.5%), cases of Chest stuffiness account for 30.1%, cases of insomnia were 21(28.8%), cases of inappetency were 20(27.4%), constipation account for 20 cases(27.4%), limb numbness saccount for 19 cases(26%).Those which have had thin white fur and weakness,associated with visual mistiness.accounting for 15 cases (20.5%)?There are 43 cases of weakness(93.5%),20 cases of visual mistiness(43.5%),18 cases of thirst and pleased drink(39.1%), cases of limb numbness(34.8%), cases of insomnia(34.8%), cases of swirl(39.1%), 13cases of thirst (28.2%), 10 cases of constipation (21.8%), among the 46 cases of thin white fur and thin dull tougue.Those which have had weakness,associated with limb numbness,accounting for 15cases (32.6%)?There are 40 cases of weakness(95.2%),28 cases of thirst and pleased drink (66.7%),18 cases of thirst and pleased drink(39.1%), 23 cases of swirl (54.8%), 19 cases of limb numbness (45.2%), 15 cases of insomnia (35.7%), 13 cases of thirst (28.2%), 14 cases of Chest stuffmess(33.3%), 13 cases of diuresis(31%), 12 cases of fear of cold and limb cold (28.6%),among the 42 cases of thin stringy pulse and thin white fur.Those which have had swirl, associated with thirst and pleased drink,accounting for 16 cases (38.1%);Those which have had limb numbness, associated with swirl, accounting for Meases (33.3%); Those which have had swirl and weakness, associated with thirst and pleased drink,accounting for 16 cases (38.1%),?There are 37 cases of weakness(90.2%),21 cases of thirst and pleased drink (51.2%), 19 cases of swirl (39.4%), 14 cases of inappetency(34.1%), 10 cases of limb numbness (24.4%), 12 cases of insomnia (29.3%),9 cases of constipation (22%),among the 41 cases of yellow greasy fur and thin dull red tougue .Those which have had thirst and pleased drink, associated with weakness,accounting for 19 cases (46.3%);Those which have had visual mistiness, associated with weakness,accounting for 16 cases (39%); Those which have had inappetency, associated with weakness,accounting for 14 cases (34.1%), Those which have had swirl and thirst and pleased drink, associated with weakness,accounting for 10 cases (24.4%); Those which have hadinapetency and weakness, associated with thirst and pleased drink,accounting for 10 cases (24.4%).?There are 37 cases of weakness(90.2%), 30 cases of thirst and pleased drink (73.3%),15 cases of visual mistiness (36.6%),13 cases of swirl (31.7%), 14 cases of limb numbness(34.1%), 13 cases of insomnia (31.7%),11 cases of constipation (26.8%),11 cases of pain of limb (26.8%),among the 41 cases of yellow greasy fur and thin dull red tougue .Those which have had thirst and pleased drink, associated with weakness,accounting for 26 cases (63.4%);Those which have had visual mistiness, associated with weakness,accounting for 15 cases (36.6%); Those which have had limb numbness , associated with thirst and pleased drink accounting for 12 cases (29.2%), Those which have had swirl, associated with thirst and pleased drink,accounting for 12 cases (29.3%); Those which have had swirl and, associated with weakness.accounting for 10 cases (24.4%).One of the common character is weakness ,it is One of the common symptoms,through analysing 6 groups of flocks of symptoms including common combination of tougue and pulse , combination of symptoms,as same as the total result of the crowds, thirst and pleased drink, visual mistiness lined with second or third place; Anohter common character is only thirst and pleased drink, there is no sympotoms of zhongxiao ,xiaxiao.The 6 groups of flocks of symptoms were not interpreted through shangxiao.On the other side, through analysing common combination of tougue and pulse , combination of symptoms, because of the difference between dull red tougue of the 2 group and thin dull tougue of 3group,seating arrangement of frequency among the common symptoms,the latter frequency of thirst and pleased drink drop into 3 place.but the frequency of visual mistiness and limd numbness ascend little.Showing Qi deficiency and yin deficiency in second group were more serious than third group.It is reasonable to interpret those by using qi and yin deficience,yin deficiency and hot excessiveness,holding hotness,holding dampness and muddy,holding dampness and hotness,holding blood stasis of three types differentiation of syndromes.3.The fenxing result of Chinese traditional medicine(l)There are 509 cases ,achieved fenxing through computers judgement,among 533 cases of T2DM,accounting for 95.6.(2) Among 509 cases of T2DM,the basic syndrome show as follow: syndrome of yin deficiency account for 286 cases(56.2%), syndrome of qi deficiency account for 233cases (45.8%) ,syndrome of yang deficiency account for 180 cases(35.4%), syndrome of hot excessiveness account for 179 cases(35.2%), syndrome of hot excessiveness account for 179 cases(35.2%), syndrome of dampness and phlegm account for 159cases(31.2%), syndrome of dampness and hotness account for 80 cases(15.7%), syndrome of blood stasis account for 350 cases(68.2%).Syndrome of yin deficiency is the most in deficiency syndromes,syndrome of Qideficiency take second place ; blood stasis syndrome is the most in excess syndrome, intense heat syndrome take second place This has proved the theory of Yin deficiency is the principal and intense heat is the mark, Syndrome of Qi deficiency and Syndrome of yin deficiency are the most familiar basic syndrome of diabetes mellitus. blood stasis is farmiliar outcome of pathology and cause of leading subsequent disease of diabetes mellitus.(3)The single and compound syndromes of 509 sufferers of T2DM :the compound syndromes have 394 cases, reaching 77.5 percent ,it is more; the single syndrome have 115 cases, reaching 22.6 percent,it is few.(4)The material syndrome of 509 sufferers of T2DM:there are 54 types in all,so the syndromes of diabetes are relatively complex. There into the material syndrome of intense heat due to yin deficiency, deficiency of both qi and yin, deficiency of both yin and yang% and concurrent syndrome have 223 cases,reaching 43.8 percent.(5)The other syndromes in group of syndrome of Qi deficiency have been statisticed.there are 16 sufferers (57.14%) that represent thirst and pleased drinking,7 sufferers (25%) that represent faitness when they look at substance; The other syndromes in group of blood stasis syndrome:lack of power 35 cases (81.4%), thirst and pleased drinking25 cases (58.1 %),being light in the head swirl 6 cases (14%), faitness when looking at substance 7 cases (25%); this shows that partial sufferers can be distinguished syndrome of deficiency of both qi and yin in two groups of syndrome of Qi deficiencyand blood stasis syndrome.(6)Classifying the sufferers of 509 cases of T2DM according to deficiency syndrome and excess syndrome: single deficiency syndrome 62 cases , multiple deficiency syndrome 10 cases ,single excess syndrome 53 cases ,thereinto blood stasis syndrome 43 cases , multiple excess syndrome 28 cases , intermingled deficiency and excess syndrome 356 cases , reaching 69.9 percent .it show that excessive syndromes of are syndrome of intermingled deficiency and excess.(7) In the three groups of leading coronary heart disease % pericranium block and nephropathy of diabetes mellitus, syndrome of deficiency of both qi and yin is maximum. Representing intense heat due to yin deficiency,the sufferers in the group of coronary heart disease are maximum; Representing deficiency of both qi and yin, the sufferers in the group of pericranium block are maximum; Representing deficiency of both yin and yang, the sufferers in the group of nephropathy are maximum.(8)In the group of coronary heart disease,the rate of representing blood stasis syndrome is the upmost,reaching 81.8%; the rate of representing damp-phlegm syndrome .. damp-heat syndrome and blood stasis syndrome are all elevatorier than nephropathy group, s (PO.05 or PO.01) .4.The result of using herbal medicine relating sufferers of T2DM:(Dthere are 2270 prescriptions relating 463 sufferers of T2DM in all, using 380 types ofherbal medicine ,31091 times, indian bread is in the most common use of Chinese traditional medicine,1181 times,reaching 52.03% percent in all prescriptions;next in turn are milkvetch root,dried/fresh rehmannia [root], largehead atractylodes rhizome, twotoothed achyranthes root, dwarf lilyturf tuber, heterophylly falsestarwort root, Chinese angelica, danshenroot, red peony root, dried tangerine peel, white peony root, oriental waterplantain rhizome, Chinese magnoliavine fruit, common anemarrhena rhizome, it shows therapeutic methods of supplementing qi, nourishing yin, promoting blood circulation for removing blood stasis, clearing heat, removing dampness and eliminating phlegm etc.(2) the primary nature and flavour of 50 types herbal forward: sweet flavours(46%), bitter flavours(34%), pungent flavours, sour flavours. It shows the rule of using herbal medicine of benefiting qi with sweet flavours, nourishing yin and clearing heat with bitter flavours, activating blood circulation with pungent flavours, promoting production of fluid with sour flavours and promoting production of yin with sour and sweet flavours.Channel entry: primary Spleen Channel(28%), Liver Channel(24%), secondary Heart Channel, Lung Channel.(3) 456 sufferers had used herbal medicine at first course of diseases,as the same as collective kinds of using herbal medicine.(4)In common use of Chinese traditional medicine in the groups of leading coronary heart disease of T2DM: indian bread, danshen root, milkvetch root, largehead atractylodes rhizome, dwarf lilyturf tuber, heterophylly falsestarwort root, dried/fresh rehmannia [root], Chinese magnoliavine fruit, twotoothed achyranthes root, snakegourd fruit,etc.We have detected the rule of using herbal medicine in this group by means of synthesizing single herbal and table of associating druggery:shengmai san join danshen yin.liujunzi tang and milkvetch root, dried/fresh rehmannia [root] are frequently used.,so to play virtue of benefiting qi and nourishing yin, promoting blood circulation and activating qi circulation, invigorating spleen for removing dampness and resolving phlegm .(5)In common use of Chinese traditional medicine in the groups of leading pericranium block of T2DM: indian bread, dried/fresh rehmannia [root], dried tangerine peel, Chinese angelica, milkvetch root, largehead atractylodes rhizome, szechwan lovage rhizome, twotoothed achyranthes root, heterophylly falsestarwort root, pinellia tuber ,etc. We have detected the rule of using herbal medicine in this group by means of synthesizing single herbal and table of associating druggery:buyanghuanwu tang,erchen tang and dried/fresh rehmannia [root] are frequently used.,so to play virtue of benefiting qi and nourishing yin, promoting blood circulation for removing obstruction in collaterals, invigorating spleen for removing dampness and resolving phlegm .(6)In common use of Chinese traditional medicine in the groups of leading nephropathy of T2DM: indian bread, milkvetch root, largehead atractylodes rhizome, dried/fresh rehmannia [root], heterophylly falsestarwort root, oriental waterplantain rhizome, dwarf lilyturf tuber,...
|
PDF Full Text Request