Ea Anti Yanglingquan, The Stroke Hemiplegic Spastic Gaba Receptor Mechanism

With the methods of molecular biology, in situ hybridization, immunohistochemistry, immunohistochemistry, radioimmunodetection, Electrophysiology, we have studied the depressant effect for hypermyotonia of experimental cerebral infarction rat and its the gamma-aminobutyric acid(GABA) receptor mechanisms first time when we simulated the GB 34 with electric acupuncture.Results: â‘ electric acupuncture can increase the GABABR1 mRNA expression in central nervous system (C.N.S), brain stem, spinal cord, cervical enlargement. It hints that electric acupuncture will enhance GABAB receptor expression and activity by influencing gene copy and transcription of GABA receptor. â‘¡electric acupuncture can boost the GABABR1 mRNA expression in brain stem, myeloid tissue. It hints that electric acupuncture can oppose GABAB receptor iunctional change which is caused by ischemia and hypoxia of cerebral apoplexy, and increase amount and. sensitivity of receptor, then it has the presynaptic and postsynaptic depressive effect. â‘¢electric acupuncture can regulate calcium ion channel state of cellular membrane and make the depressive effect by influencing the level of second messenger cAMP after couple between GABAB receptor and G protein. ? H reflex recovery curve examimation shows that electric acupuncture can obviously suppress neuron excitability of motor neuron pool in cornu anterius medullae spinalis, decrease accentuatal tension of muscle and Liddell and Sherrington reflex.Conclusions: electric acupuncture can relieve spasm of limbs after cerebral apoplexy. It' s because of that electric acupuncture can increase amino acids transmitter (GABA_B receptor) expression, increase...