The Protective Effect Of Enteral Nutrition And Astragalus Obstructive Jaundice Gut Barrier And Liver Damage

Backgrounds:Infantile obstructive jaundice (OJ),a common symptom of congenital biliary atresia,biliary dilatation,and biliary dysplasia, often associates with systemic and local immune dysfunction,malnutrition,gut barrier dysfunction. Biliary obstruction promotes intestinal bacterial translocation and endotoxemia and this process is an important cause of gut-related sepsis,mutiple organ and system dysfunction syndrome in patients with jaundice. In previous OJ rat model, ileal inflammation, edema,the formation of lateral spaces between enterocytes,and increased enteric bacteria number attached to intestinal mucosa were found. Total parenteral nutrition may lead to decrease of tight junction between intestinal epithelial cells and secretory immunoglobulin A content in intestinal lumen. While hepatic portal vein is depressed by dilated common bile duct in OJ,intestinal blood flow and intestinal absorptive function of nutrients decreases.Objective:The aims of this study were to estabolish obstructive jaundice model in growing rats and imitate the pathophysilogic status of infantile obstructive jaundice and to analyze objectively intestinal mucosal morphometric characteristics, to examine the evidence of bacterial translocation, and to assess ultrastrucrural abnormalities of enterocytes.The study also focused on the pretective effect of enteral nutrition on gut integrity in immature rats with obstructive jaundice.Material and methods: Forty growing male Wistar rats were randomly divided into...