| Although a gratifying improvement in the success rate of organ transplantation has been taken place in decades, the acute and chronic rejection are still the major complicationsand the top causes of allograft failure. The immunosuppressive agents now used clinically have usuallycertain toxicities and side effects, To develop high -efficient and low-toxic immunosuppressive agent6 is therefor an important subject in transplant fields. Tripterygium wilfordii Hook f, which is a traditional Chinese medicine, has been proved to be a strongly immunosuppressive drug both in cellular and humoral immunity, Tripchlorolide (T4), anew compound isolated from the Multi- Glycosides of Triterygium Wilfordii Hook f (GTW) lately, has been showed with the same immunosuppressive activities as GTW and lower toxicities and side effects than GTW. Whereas its potency was 100 ~ 200 times stronger than GTW in preliminary pharmacologic assay. The purpose of this study is to investigate the anti- rejection action and explore the possible mechanism of anti-rejection of T4,To evaluate the role of anti-rejectin of T4, in the first part of this study, we established the stab1 heart allograft model in Wastar rats . In the second , we investigated the mean survival time (MST) of the cardiac allografts and... |
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