Not Typical Of Secondary Syphilis Some Immunology,

Objective To investigate the immunologic changes of parients with the secondary syphilis. Methods Rapid plasma reagin(RPR) test, treponema pallidum haemagglutination assay(TPHA) test and treponema pallidum particle assay(TPPA) test, were used to detect the secondary syphilis, flow cytometry was used to detect DC subsets in peripheral blood and ELISA method was used to detect the serum level of IL-12, IFN-r in patients with the secondary syphilis and the healthy controls. Results The expression of RPR, TPHA and TPPA in the secondary syphilis patients increased more significantly than that in normal controls. The expression of CD11c ~+DC was (2.51±1.26)％in peripheral blood in the secondary syphilis patients, increased more significantly than that in normal controls(0.41±0.19)％. The expression of CD123 ~+DC in peripheral blood in secondary syphilis patients was(0.34±0.17)％, with no significant difference compared with that in controls(0.34±0.14)％. The serum level of IL-12 and IFN-r were (28.08±12.34) pg/mL, (4.10±3.24) pg/mL in the secondary syphilis patients, increased more significantly than that in normal controls(0.65±0.17) pg/mL, (0.27±0.21) pg/mL. Conclusion Be similar to pityriasis rosea with lymphadenectasis had correlation with the changes of RPR test, TPHA test and TPPA test. Treponema pallidum mainly induced the expression of CD11c ~+DC and initiated cell-mediated immune response. IL-12 and IFN-r might take part in the immune processes after treponema pallidum entering into body, and play a prominent role in treponema pallidum clearance. Be similar to pityriasis rosea with lymphadenectasis had correlation with the changes of CD11c ~+DC, CD123 ~+DC, IL-12 and IFN-r.