The Subthalamic Nucleus Nuclear Magnetic Resonance Imaging Three-dimensionally Reconstructed And Curative Effect Of Deep Brain Stimulation Of Parkinson's Disease Study

SECTION 1 Subthalamic nucleus Visualization of three- dimensionally reconstructedObjective:Exploring three-dimensional reconstruction of magnetic resonance imaging technology to the measurements of healthy control and parameters of patients of Parkinson's disease subthalamic nucleus of visualization the three-dimensional reconstruction and size and so on.Method:Randomly selected 16 cases of healthy adults over 40 years of age andⅠSTN-DBS Bank hospital treatment of the detailed information in the choice of Parkinson's disease 6 cases of bilateral STN-DBS said MRI three-dimensional reconstruction.And measure the size of the subthalamic nucleus and three-dimensional parameters.Result:MRI three-dimensional reconstruction can be clear indications that the subthalamic nucleus of the three-dimensional conformation, lines smooth,sleek appearance.40-49 year-old group STN volume average is 138.85±7.04mm,50-59-year-old group is 118.34±13.04mm3,above 60 years of age group is 1109.88±11.37 mm3 suggested that growth in volume decreases with age,the volume of bilateral subthalamic nucleus comparison left is 125.775±15.05mm3,right is 118.46±16.59mm3 suggested that the left subthalamic nucleus right size larger than the male average is 129.31±15.02 mm3 female average is 114.90±13.92 mm3 subthalamic nucleus size male than female,are in different age groups this feature.The subthalamic nucleus in Parkinson's disease group volume of bilateral mm3 average is 82.72±9.22, 85.36±9.83 mm3in left,right is 80.08±8.78 mm3,smaller than the normal age group.Although MRI three-dimensional reconstruction effective,takes a longer time to check all clinical,there are certain difficulties complete clinical application,but as technology advances it will become stereotactic neurosurgery indispensable tool.Conclusion:MRI three-dimensional reconstruction can be good redevelopment SIN. STN volume growth decreases with age,the left more than the right,men more than women,healthy people than Parkinson's disease.Although the use of certain problems there are bright prospects for its development.SECTION 2 Correlative factors analysis of the target localizationObjective:Discussing Parkinson's disease on the subthalamic nucleus deep brain stimulation of the target location relevant factors.Method:Recalling my hospital STN-DBS in the treatment of Parkinson's disease have detailed information on the 23 cases, six of them routine MRI and three-dimensionally reconstructed reconstruction,line of Yao preoperative used to be location for the installation of the light planes before surgey,MRI image positioning of target coordinates,microelectrode recording in the surgey,temporary brain stimulation electrodes,the C-arm machine perspective,in the review of MRI to verify the actual position of electrode means target location and verification.Results:MRI can cause abnormal stimulator turned on or off,but the frequency and pulse width parameters were not affected,inspection before stimulator voltage set to 0 avoidable accidents.DBS MRI examination is not taboo.After review of the long-term follow-up of patients with MRI images and immediately after the review of the MRI found no shift electrode position,immediately after the review of the MRI images can be used as a stimulus determine the actual electrode contacts basis.This group preoperative MRI positioning coordinates and the electrode tip actual location,the results showed that in addition to X coordinates left no significant difference,and the remaining coordinates direction there are noticeable differences.Opened right next to the most obvious direction of inward migration.This group the best position to stimulate the STN:X=11.45±1.39 mm,Y=-1.87±1.56 mm, Z=-2.01±1.9mm STN display on the outside of the Department of stimulating a better effect.Conclusions:MRI examination is safe to DBS,the STN's MRI images directly positioning accurate and reliable.MRI immediately after the review of the image data can be used as a stimulus determine the actual electrode contact basis.In the upper part of the STN to stimulate a better effect.