Research On Effect Of Artificial Loading To Rat Tibia Of Disuse-Osteoporosis

Osteoporosis is a worldwide frequent disease in aged people, which gets more serious and higher incidence annually with the aging of the world's population but easily neglected. Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Many researchers have been researching the biomechanics and biology of bone for over a century and achieved a lot of accomplishment, but the coupling realationship between biological factor and mechanics factor in the regulate and control of bone metabolization is still not distinct, calculation model of osteoporosis is still seldom seen in domestic and international reports. We are supported by National Nature Found of China to research the coupling realationship between biological factor and mechanics factor in the regulate and control of bone metabolization in osteoporosis and computer simulation, this paper is one experimental part of this item. According to the results of these experiments, we can draw some conclusions as follows: 1. Based on the theory of bone functional adaptability, a better rat model of osteoporosis was attained from the experiment of tail suspending after 4 weeks.2. A dynamic axially living animal loading system was devised and tested to be credible and precise, and the realationship bteween loading and the strain of rat tibia was tested.3.The artificial loading could pervent the reduce of mechanical performance and bone histomorphometry of suspended rats'tibia as effective as the daily activity, this means an adequate loading was necessary to maintain bone mass and biomechanical capability, and we conclude that the MESr of 9-month-old rat's tibia was appoximitly 90με.