| Objective:to discuss the clinical curative effect of NiuJiaoDiHuan decoction on treatment of Chronic idiopathic thrombocytopenic purpura with YinXuXueRe and it's mechanism on ITP experimental ratsMethods:1 Clinical Study:65cases of patients with CITP were divided into two groups randomly (Chinese medicine treatment group, western medicine control group), and were treated with NiuJiaoDiHuan decoction, Prednisone respectively for 6 months. The curative effect, Chinese medical syndromes, clinical efficacy, blood platelet, megakaryocyte of bone marrow, side effect, and prostecdtive efficacy were observed. Moreover, all of above were compared between treatment and control group.2 Experimental Study:Abdominal cavity injection of APS was given everyday to rats for the mode of ITP. Through the rat mode of ITP,Fc gamma receptor II b (FcγII b) on Spleen Macrophage were tested by Immunity fluorescence technology,Membrane attack complexe (MAC) and Blood platelet related immune body (PAIgG) on Blood serum were tested by ELISA. Results:1 Clinical Study:About Chinese medical syndromes, clinical efficacy, blood platelet, megakaryocyte of bone marrow,the results showed there were Obvious curative effect compared to treatment before on the two groups patients (P< 0.05); NiuJiaoDiHuan decoction treating CITP made better to the therapeutic group than the control group about Chinese medical syndromes, prostecdtive efficacy,Wuxingfangre,mouth does, constipation (P< 0.05),but showed a contrary results about increasing velocity of blood platelet, Dizziness (P< 0.05). About clinical efficacy, Quantity of blood platelet, megakaryocyte of bone marrow and Hemorrhage symptom, there were no significant difference between the two groups (P> 0.05);After been observating for one year, obvious side effect on the patients of therapeutic group were not discovered.2 Experimental Study:In the three groups rat mode of ITP,the sorting of the expression of the FcγⅡb on Spleen Macrophage is medicine group>normal group>model group, moreover, there is significant difference of the expression of the Fc y II b on the medicine group compared with the other two groups (P< 0.05),but there is no statistic significance between the normal group and the model group (P>0.05).There is no statistic significance of the quantity of the MAC on Blood serum between the medicine group and the model group(P>0.05), but about the PAIgG, the diffrence between the two groups is significant (P<0.05)。Conclusion:1 NiuJiaoDiHuang decoction is effective in treating chronic idiopathic thrombocytopenic purpura with YinXuXueRe, and it has characters as wide safety scope and good security utilities,and the prostecdtive efficacy of NiuJiaoDiHuang decoction is better than Prednisone's,but inferior to prednisone in increasing velocity of blood platelet.2 The mechanism of the NiuJiaoDiHuang decoction in preventing blood platelet from the destruction is to increase the expression of the Fc y II b on Spleen Macrophage and intervent the combine of the PAIgG to blood platelet.
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