Study On The Influence Factors Of Oriented Efficacy Exertion Of Dahuang (Radix Et Rhizoma Rhei) In Formula

Objective:To research the regulating factors that controlling the function of Dahuang(Radix Acanthopanax Senticosi) in formula.To reveal the basic regulation of prescription composition, dosage in most use, the best preparation, boiling and usage of Dahuang that display various effects in formula.Methods:According to the classic format Formula Dictionary of Traditional Chinese Medicine,1224 formulae including Dahuang were collected and structured data bank in Micro-Excel. To statistics the high frequency medicine compatibility with Dahuang, dosage in most use, the best preparation, decocting and usage of taking special effects. Consulting various historical documents of Traditional Chinese Medicine after Treatise on Febrile and Miscellaneous and Sheng Nong's herbal classic, modern periodical magazine and research monograph about Dahuang. To sun up regulating factors that affecting the direction of function of Dahuang, and discussing it with relevant pathogenesis.Result:The five kinds of concluded Dahuang's efficacy and 15 functional exertion are dispelling diarrhea and purge substantial Evil(expel Heat to loosen the bowels,purge away constipation duo to accumulation of Cold, purge away dyspepsia, detoxicate and kill parasites, expel Fluid-retention), dispel Heat and remove toxin(dispel Heat to relieve thoraxic, clear away heart-fire, clear away Lung-Heat and Intestine-Heat, purge Liver-fire, clear away Heat and promote diuresis, clear away Heat to remove carbuncle, detoxicate to remove sore), promote Blood circulation to dissipate Blood stasis (promote Blood circulation to induce menstruation, promote Blood circulation to relieve pain, promote Blood circulation to remove stagnancy), coll Blood for hemostasis, promote the function of the gallbladder to alleviate jaundice.The regulation factors that controlling functional exertion of Dahuang in formula are the circumstances of compatibility, dosage, processing of preparation, preparation,usage and boiling.The circumstances of compatibility are the most important regulating factors. When exerting function of dispelling diarrhea and purge substantial Evil, Radix Acanthopanax Senticosi is usually made up a prescription with Natrii Sulfas, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Semen Arecae, Radix Euphorbiae Kansuil, Semen Pharbitidis, Fructus Cannabia, Semen Armeniacae Amarum and so on. With Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Fructus Forsythiae, Gypsum Fibrosum, Caulis Clematidis Armandii,Talcum, Radix GenTianae, Herba Dianthi, Calculus Bovis, Cornu Rhinoceri Asiatici, Semen Coicis, Semen Benincasae, Alumen, Rhizoma Bletillae and so on, Radix Acanthopanax Senticosi is praescribed for dispel Heat and remove toxin. With Radix Angelicae Sinensis, Rhizoma Ligustici Chuanxiong, Semen Persicae, Flos Carthami, Rhizoma Sparganii, Rhizoma Zedoariae, Tabanus, Hirudo and so on, for promote Blood circulation to dissipate Blood stasis. With Cortex Moutan Radicis, Radix Rehmanniae, Radix Sanguisorbae, Pollen Typhae, for coll Blood for hemostasis.With Herba Artemisiae Scopariae, Fructus Gardeniae, for promote the function of the gallbladder to alleviate jaundice.As for the other factors, Dahuang was more different in doseage because different medicinal materials, circumstances of compatibility, dosage, processing of preparation, region natural environment, physique of patient and so on.but generally speaking, the doseage of Dahuang have two regulation:â‘ . It employed as dispel Heat to relieve thoraxic and clear away Heat and promote diuresis shoud be less, mostly for dispelling diarrhea and purge substantial Evil and coll Blood for hemostasis, intermediatly for promote Blood circulation to dissipate Blood stasis and dispel Heat and remove toxin.â‘¡the doseage of Dahuang employed as disease involving both Exterior and Interior should be less, mostly for Exterior harmony and Interior-Excess. Raw Dahuang was often used in the function of diarrhea and purge substantial Evil, dispel Heat to relieve thoraxic, detoxicate to remove sore, coll Blood for hemostasis;Wine Dahuang was often used in promote Blood circulation to dissipate Blood stasis and lead other medicine to Shangjiao;processed Dahuang was used in the patient with a weak constitution; Dahuang charcoal was often used in the function of hemostasis. Decoction, pill, paste and powder is four kinds of preparation of Dahuang most in use. Decoction apply to all kinds of function; pill is often used in diarrhea and purge substantial Evil, dispel Heat and remove toxin, promote Blood circulation to dissipate Blood stasis and less used in coll Blood for hemostasis and promote the function of the gallbladder to alleviate jaundice; powder is often used in diarrhea and purge substantial Evil, dispel Heat and remove toxin, promote Blood circulation to dissipate Blood stasis, coll Blood for hemostasis and less used in promote the function of the gallbladder to alleviate jaundice; paste is often used in pyogenic infection of skin.Conclusion:The compatibility is the key point of all the factors influencing the efficacy exertion of Dahuang.What's more,other factors including compatibility, dosage, processing of preparation, preparation and so on are also influential in it. Therefore, the efficacy exertion of Dahuang in compound formulae is influenced by all the factors we mentioned above.