| Objective:To investigate the effects of Huichunpiantan Decoction(HD) under guidance of the theory of tonifying liver and kidney and activating blood circulation on treating stroke models of rats after experimental cerebral ischemia (CI).Methods:The rats after successful modeling the models of middle cerebral artery occlusion (MCAO) were randomized into six groups:sham operation group, model group, high dose group, middle dose group, low dose group and control group. After 14 days treatment course, the changes of weight, behavior, infarct size, the structures of brain tissue, the contents of SOD, MDA, GIu, NGF in brain, and the expressions of BDNF, GAP-43, SYN were investigated.Results:①HD decreases neural functional deficits in the evaluation of rats and the score with long medication was lower, suggesting that medication can even better improve neural functional deficits;②HD could obviously reduce the infarct size;③HD could increase SOD activity, reducing MDA and Glu content in brain;④HD could markedly increase the content of NGF in brain;⑤HD could protect the structures of brain tissue in experimental cerebral ischemia rats;⑥HD could significantly promote the expression of BDNF in brain;⑦HD could promote the expressions of Gap-43 and SYN.Conclusions:The experiment shows that HD as an effective decoction by tonifying liver and kidney and activating blood circulation can improve neuronal functional recovery in CI.
|
PDF Full Text Request