| Coronary Atherosclerotic Heart Disease CAD is mostly happen to middle-aged or older people, with improvement in people's living condition and c hange of their diet habit, there is a trend of increasingly younger peopl e having CAD. Today CAD and Stroke are two main diseases that lead to hig hest rate of disability and death in China, and continue be a major threa t to peoples'health and lives. A large number of research have concluded that Carotid Arterioles Atherosclerosis CAS and CAD have same dangerous f actors and common mechanism, there are close relationships between the tw o. CAS happens earlier than other Arthroscleroses AS, and thus can be use d as a window to detect CAD. Early stages CAD are normally with no sympto m and very difficult to detect, therefore most patient missed proper and timely treatment. Nowadays with the advancement in ultrasonic technology and method, the ultrasonic scanning of CAS become an effective method of detecting CAD in its early stage, and this is very important to prevent a nd decrease incidences of CAD and most Cardiovascular and Cerebrovascular Diseases CCVD. Traditional Chinese Medicine has its superiority and dist inction in treatment of CAD and CAS diseases, and Bushenhuoxuehuatan meth od has already been widely used in treatment of Angina Pectoris. This res earch is an innovative study; the value is to study the curative effects on Atherosclerotic plaque in Carotid artery when treating patients of Ang ina Pectoris of CAD by Bushenhuoxuehuatan Decoction, and at the same tim e investigate the curative effect on other CCVD symptoms as well. Bushenh uoxuehuatan Decoction is invented by my tutor, Guangdong famous TCM prac titioner, Specialist of Internal medicine Shenzhen Hospital of TCM, Profe ssor LUO Luyi, the decoction is a pure Chinese medicine composition and h as been tested and refined for over forty years of clinical practices tre ating AS diseases. Based on the concept that root cause of AS is kidney i nsufficiency, and the incidental factors are blood stasis, and phlegm-hu mor stagnation, Professor LUO tailored the decoction which mainly compose d of Rehmannia glutinosa, Psoralea corylifolia, Polygonum multiflorum, Ac hyranthes bidentata Blume, Pinellia ternate, Arisaema consanguineum Schot t., Acorus gramineus Soland and Ligusticum chuanxiong Hort.Purpose:Observing the curative effects on Atherosclerotic plaque in Carotid artery when treating Angina Pectoris patients with Bushenhuoxuehuatan Decoction, thus to provide additional research justification for the effectiveness and refinement of the decoction.Methods:192 valid patients were divided into treatment group T, control group A and foundation group B by the simple randomization. All cases for all thr ee groups were given the same foundation treatment:Apsin (one 100mg tabl et at night per day).The treatment group T was treated with Bushenhuoxueh uatan Decoction (one dose per day separately half portion warmly taken mo rning and at night), while control group A was treated by the Atorvastati n calcium (one 10mg tablet at night per day) and foundation group B was t reated only by foundation treatment.90 days would be a course of treatme nt for all three groups, and two courses of treatment were observed. The type and quantities of CAS plaques, intima-media thickness (IMT), plaques area and Crouse scores were detected by Ultrasonic scanning. The patient s'symptoms, Angina Pectoris symptoms, electrocardiogram, hepatic functio n, renal function, electrolytes examination and the three main routine ex aminations before and after the treatment of the three groups were detect ed. And as well as hemo-axungia examination, C-reactive protein measureme nt and hemorheology examination were detected as well. Then, the data woul d be analyzed by statistical analysis to get the results and conclusion.Result:The curative effect of the Bushenhuoxuehuatan Decoction is described as follow:For CAS curative effect, predominant effect rate 46.03%, total effect rate 83.87%, there are no significant difference with Atorvastatin calcium control group A(P>0.05), but there are very significant difference with foundation treatment foundation group B(P<0.01). Treatment group T has significantly reduced the quantities of plaques for all types of CAS plaques, total quantity reduced from 128 to 89, there are very significant difference before and after treatment(P<0.01), and there are no significant difference with control group A(P>0.05), but there are very significant difference with foundation group B(P<0.01). Treatment group T has very significantly reduced the intima-media thickness (IMT), very significantly reduced plaques area and very significantly reduced Crouse scores, there are very significant difference (P<0.01). However there are no significant difference between treatment group T and control group A & foundation group B (P>0.05), except on Crouse scores that Treatment group T and foundation group B has very significant difference(P<0.01); Angina Pectoris cure rate 42.86%, predominant effect rate 50.79%, total effect rate 87.3%. Electrocardiogram predominant effect rate 52.38%, total effect rate 87.3%. For curative effect on the extend of Angina Pectoris attacks, Angina Pectoris symptoms, Electrocardiogram cure rate, and the total Angina Pectoris cure rate, Bushenhuoxuehuatan Decoction treatment group is more effective than Atorvastatin calcium control group A and foundation treatment foundation group B, there is very significant difference between treatment group T and the two other groups (P<0.01); Total TCM Symptom Integral predominant effect rate 47.62%, total effect rate 85.71%. All individual TCM Symptom are improved after treatment except memory improvement, (P<0.01), there is very significant difference. Treatment group is more effective than two other groups except memory and eyesight improvements, there are very significant and significant difference between the groups (P<0.01 or P<0.05); In hemo-axungia examination, treatment group T has significant curative effect in lowering TG, TC, LDL-C, while rising HDL-C values, there are very significant difference (P<0.01) after treatment. However there are no significant difference with control group A (P>0.05), and no significant difference with foundation group B (P>0.05)on TC, LDL-C, but has very significant difference with foundation group B (P<0.01) on TG, HDL-C; After treatment, treatment group T has significant reduced C-reactive protein (CRP) value, there are very significant difference (P<0.01). Compared to control groups, there are no significant difference with control group A (P>0.05), but has very significant difference with foundation group B (P<0.01); In hemorheology examination, treatment group has significantly reduced blood viscosity (high and low cut), plasma viscosity, and hematocrit, there are very significant difference (P<0.01). However there are no significant difference between treatment and two other groups (P>0.05) except for plasma viscosity there are very significant difference between treatment and control groups (P<0.01). Finally after straight line correlation analysis, Angina Pectoris symptom scores and IMT has shown direct positive relationship, correlation factor 0.819, P=0.000<0.01, has very significant statistical meaning.Conclusions:The Bushenhuoxuehuatan Decoction has outstanding curative effect on Angina Pectoris of Coronary Heart Disease, and at the same time all CAS symptoms of the patient were significantly improved, in the entire course of treatment no adverse drug reaction was observed. Bushenhuoxuehuatan Decoction, with its functions of adjusting the hemo-axungia, reduce C-reactive protein and improving hemorheology, could hinder and defer CAS plaque development, improve symptoms of CCVD, protect and cure CAS and AS diseases, and ultimately prevent and decrease incidences of CAD and most CCVD Diseases...
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