| Objective:1.Through 20 cases of coronary heart disease stable angina phlegm heat and blood stasis resistance syndrome in patients with clinical observation,to explore musk macaroni dropping pill for coronary heart disease patients with stable angina pectoris angina symptoms improvement,blood lipid and serum lipid element influence the mechanism of action.2.By high-fat feeding and pituitrin injection duplicate the model of atherosclerosis,observe the musk macaroni dropping of atherosclerosis in rats blood lipid and serum lipid element,abdominal aortic and carotid artery intima pathological changes and the effect of explore musk through heart dropping pill on the mechanism of action of atherosclerosis.Methods:1?Clinical research methods:Will come from heilongjiang university of Chinese medicine the first affiliated hospital outpatient service of 20 patients with coronary heart disease angina pectoris(phlegm heat and blood stasis resistance syndrome)were randomly divided into treatment group(conventional western medicine tiaozhi crown treatment with musk,antiplatelet aggregation,enlarge tong heart dropping pill),10 cases in the control group(conventional western medicine tiaozhi crown treatment with musk,antiplatelet aggregation,enlarge tong heart dropping pill placebo)10 cases.Take two pills three times a day.Therapy of 56 days.To observe the improvement of the symptoms of angina,the change of blood lipid and serum lipids.2?Animal experiment method:The male SD rats were 60,15 were left in the control group,and the remaining 45 were injected with the abdominal cavity and then the vasopressin was reared and the atherosclerosis model was copied,8 weeks after the blank control group randomly take 3,module only take nine rats blood lipid changes in venous blood detection,abdominal aortic and carotid artery for confirmed HE dyeing observation artery intima copy the successful model.The successful rats were randomly divided into the control group,the Chinese medicine treatment group,the western medicine control group,each group of 12.From the 9th week,the Chinese medicine treatment group was filled with the musktonic pill(which contains 10.94 mg/kg/kg).The control group of the western medicine was given the contents of the contents of the contents of the contents of the contents of the contents of the contents of the drug.The other two groups were filled with the same volume of distilled water.After eight weeks in the stomach,the blood and serum lipids were detected by ELISA method,and the main and carotid arteries were used to observe the changes in angiopathological morphology.Result:1?Through clinical observation:(1)The total score of angina pectoris in the treatment group was lower than that before the medication,the difference was statistically significant(P<0.01).Compared with the control group,the total scores of angina pectoris in the experimental group were obviously lower,the difference was statistically significant(P<0.05).(2)Blood fat:The levels of TC,TG and LDL-C in the experimental group were lower than those before the treatment,and the level of HDL-C was significantly higher than that before the treatment,and the difference was statistically significant(P<0.01);Compared with the control group,the levels of TC,TG and LDL-C in the experimental group were decreased,and the level of HDL-C increased,the difference was statistically significant(P<0.05).(3)Serotonin:Serum visfatin levels were significantly lower than the treatment group after treatment before treatment,the difference was statistically significant(P<0.01);Compared with the control group,serum visfatin levels were significantly decreased in experimental group after treatment,the difference was statistically significant(P<0.05).2?Through animal experiments found that:(1)blood fats:Blank control group,the traditional Chinese medicine treatment group,western medicine control group compared with model control group,blood lipid level of TC,TG,LDL-C was lower,the level of HDL-C rise,statistically significant difference(P<0.05);Compared with traditional Chinese medicine treatment group,western medicine control group was very effective,and the difference was not statistically significant(P>0.05).(2)Serum visfatin:The levels of serum lipids in the control group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Compared with traditional Chinese medicine treatment group,western medicine control group was very effective,and the difference was not statistically significant(P>0.05).(3)The pathological results showed:In addition to the blank control group,each group in the arterial lumen intima irregular thickening,disordered arrangement of smooth muscle and elastic membrane rupture,tube weeks numerous foam cells and lipid,mild inflammatory cells infiltration.In the treatment group of traditional Chinese medicine and the control group of the western medicine,the vascular wall and the control of the tube were decreased,the smooth muscle cells were less swollen and the inflammatory cells were decreased.Conclusion:1?Clinical observation:Musk macaroni dripping pills can significantly improve patients with stable angina pectoris of coronary heart disease of phlegm heat and blood stasis syndrome of angina symptoms,reduce angina attack frequency,duration and extent;reduce the serum visfatin,TC,TG,LDL-C,HDL-C of patients with elevated level.2?Animal studies have found that the heart drops of musktonic pill can reduce atherosclerosis model rats' TC,TG,LDL-C,serum lipids,and raise the HDL-C level of rats.Improved arterial damage in rats. |
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