| Objective:1 An analysis of the general situation of the Institute to collect medical history; explore tutor's thinking path of the inhibiting wood and strengthening earth; summary mentor prescription and drug law; explore rules and characteristics of Tourette's syndrome elements and its target site2 To explore the data-oriented approach to TCM expert clinical experience of finishing the feasibility of mining.3 To observe impact of content of monoamine neurotransmitter in brain of model mice built by IDPN intraperitoneal injection after taking herbal medicine, so as to understand possible mechanism of TCM treatment of TS.Methods:1 Traditional research methods integrated with computer information technology method in accordance with the "man-machine combination of expert-based" principle are used to analyze syndrome-rule-prescription-drug laws, and summary the experience and academical academic treatment of TS of tutor..2 Analysis and summarise the law of element factor of symptom complex of TS, and do a preliminary exploration for the standardization of research to TS symptom complex.3 To observe impact of monoamine neurotransmitter in brain of IDPN-induced model mice by taking liu jun zi tang and xie qing wan, Tiapridal is used as control medicine.Results:1General information102 children are studied,Boys outnumber girls in the ratio of 5.38to 1, and this consistent with previous literature reports. the minimum onset age was 2 years old; the maximum was 15, and average age 7.05.36 cases were 2-6-year-old period (35.29%); 40 cases were 6-9 -year-old (39.22%).attendance tic grade:low grade 75 cases (73.53%), moderate grade 27 cases (26.47%).66 cases are accompanied with ADHD,5 cases accompanied with Obsession,4 cases accompanied with Sleep disorder,1 cases accompanied with attack behaviour. there are 90 children with hot temper or timidity accounting for 88.26%.51 cases Trace Elements are normal,29 cases Trace Elements are abnormal. Patients with a blink of eye as first symptom account for 73, and HangHang for 17 cases. 2 Experience of treatment of Tourette syndromeThe survey shows that splenic asthenia and liver domination was the most frequent TCM syndrome for Tourette syndrome, It followed by stagnated QI transforming into fire, Next syndrome was spleen asthenia and poly-sputum, stirring of wind due to deficiency of YIN was the least.syndrome factor whose occurrence Frequency exceed 5%are wind factor (24.12%), heat factor (23.82%), sputum factor(22.68%), Yin deficiency factor (12.06%), Qi deficiency factor (12.06%).there are many integrated styles, sputum factor+wind factor+heat factor+X is the most popular. The disease location is relative with spleen and liver mostly, summing up to 271 cases (39.91%).62 treatment rules are used by my tutor in curing TS, including trsnquilizing endogenous wind, followed by reducing phlegm, invigorate the spleen, soothing the liver, ect.The Principle of Prescription:during all compound recipes, ER CHEN TANG combined with XIE QING WAN is used for 78 times, SI JUN ZI TANG combined with XIE QING WAN is used for 48 times, LIU JUN ZI TANG combined with XIE QING WAN is used for 12 times.The Principle of using herbs:the most use of frequence are Fangfeng, followed by Mugua, Shenjincao,Gengeng, Dilong, Juhua, Gujingcao, Wushaoshe,etc.Monoamine neurotransmitter in brain of TS model mice:compared with blank controller, NA content in brain of Tiapridal group and compound recipes increase obviously, compared with modeling team,5-HIAA content in brain of Tiapridal group and compound recipes increase obviously (P< 0.01)Conclusion:1 Tourette syndrome has the highest incidence in preschool and school-age, incidence of boys is higher than girls. tic degree of different gender, the age at onset, and different course of the disease was no significant difference. the first symptom of studies have shown that eye blink is a sports tic in the most common, Hang Hang is a vocal tic in the most common. TS is associated with a variety of behavioral problems such as OB, SD, ADHD, etc. mild emotional disturbances and abnormal trace elements in blood lead increased should be focused in the prevention and treatment of TS.2 Article can be concluded from the syndrome, syndrome elements that TS disease is based on "wind, phlegm," target is in liver and spleen, treatment rules is inhibiting wood and strengthening earth3 Laws of syndrome elements and their combinations show a complex pathogenesis of this disease, syndrome factors include wind, heat, phlegm, qi deficiency, yin deficiency mainly. Wind+heat+sputum (+X) is common in syndrome factor combination.syndrome factor target site is mainly in the liver, spleen. combined with elements and their target site, we can conducted:The pathogenesis of this disease is mainly poly sputum Spleen, liver Kang wind-driven. the most information of the disease can be summarized by fewer syndrome elements, so that people is more easy to understand Tourette's syndrome. it also bears out tutor's academic thinking. from elements of the syndrome4 Verification of the use of information technology relying on a "man-machine integration, expert-based" approach to Chinese medicine experts's clinical experience is feasible.5 Effect of Chinese herbal compound curing Tourette's syndrome may be achieved through the following mechanisms:(1) inhibition of excessive dopamine nerve domination or super-sensitive dopamine receptor; (2)according to 5-HIAA levels increased,5-HT levels may be increased,5-HT plays a role in inhibiting tic; (3) the level or activity of dopamine-hydroxylase (DβH) may be increased to transform dopamine into norepinephrine.
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