| Tourette Syndrome (TS) is named for Gilles de la Tourette, a French physician. This disease is a type of tic disorder. Tourette Syndrome is an inherited neurological disorder characterized by multiple involuntary movements and uncontrollable vocalizations called tics. The tics always appear suddenly even though during the speaking and working. The tics behavior can also affect the other people under the severe condition. Patients with Tourette Syndrome often come to feel that their social isolation, vocational or academic failure. According to the research of etiological factor and associated symptoms, the frequently used drugs include Haloperidol, pemozide, flumezine, fluazine and so on. Although these drugs can decrease the motor tics and vocal tics, they can not avoid the extrapyramidal effects such as convulsion, tardive dyskinesia, akathisia, and conscious disturbance. If these drugs are not used the original symptoms can be possibly aggravated. Therefore it is important to develop a new medicine of the TS treatment from the Traditional Chinese Herbals.In this work I studied the pharmacological effects and possible mechanisms of Xi Feng Jing Ning Recipe (XFJNR) in treating TS.Results:1. General pharmacological effect of XFJNR on central system1.1 Effect of XFJNR on spontaneous locomotor activity of mice: Mice were single and successively 5 days administrated with XFJNR. Results showed that the locomotor activities in the mice treated with XFJNR at the doses of 10g/kg, 5g/kg were decreased compared with control (P<0.01, P<0.05)1.2 Hypnotic effect of XFJNR on mice: XFJNR was administrated single and successively 5 day to the mice. Pentobarbital ip or chloral hydrate was ip after 1.5 hours at the last dosage. Results showed that the pentobarbital- and chloral hydrate-induced-hypnosis period was prolonged in mice receiving XFJNR at the doses of 10g/kg, 5g/kg (P<0.01).1.3 Effect of XFJNR on increased locomotor activity of mice induced by scopolamine: Experimental animals were injected Scopolamine to induce the high spontaneous activity. Results showed that single administration, three doses of XFJNR (10g/kg, 5g/kg, 2.5g/kg) could decrease the increased locomotor activity induced by scopolamine (P<0.05 compared with control).2. Effects of XFJNR on TS model2.1 Effect of XFJNR on increased locomotor activity of mice induced by amphetamine: Experimental animals were injected Amph to induce the increased spontaneous activity. It was found that XFJNR 5g/kg, 2.5g/kg for five days administration could decrease the amphetamine-induced high locomotor activity (P<0.01, compared with Amph group).2.2 Effect of XFJNR on increased climbing behavior of mice induced by apomorphine:Experimental animals were injected Apo to induce the increased climbing behavior. It was found that three doses of XFJNR for five days administration could decrease the apomorphine-induced climbing behavior in rats (P<0.01. compared with APO group).2.3 Effect of XFJNR on Rat's stereotyped behavior: Experimental animals were randomly divided into six groups, the normal control group, the APO group, the Haloperidol treated group, and the XFJNR treated groups (8g/kg, 4g/kg, Ig/kg). At the end of the first and fifth treatment, except the normal control group, each group administrated apomorphine to arouse the stereotyped behavior. The behavior scores were record to evaluate the effect of the treatment. Compared with APO group, the scores of stereotyped behavior decreased by the treatment of XFJNR (P<0.05,P<0.01).2.4 Effect of XFJNR on Rotational Behavior in Rats: Experimental animals were unilateral nigral lessoned (right side) by micro-injection of 6-OHDA. The rats with obvious rotational behavior induced by APO were chosen to carry out the test. It was found that XFJNR could significantly antagonize the rotational behavior (P<0.01). and was consistent with the effect of positive drug-llaloperidol.2.5. Effect of XFJNR on head-twitch model induced by 5-HTP in mice: Experim... |
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