Studies On Transition Metai Catalyzed1,2-Difunctionalization Of Alkenes

The difunctionalization of alkenes is a powerful strategy for the synthesis of various organic compounds. Recent studies have demonstrated that transition metal catalyzed transformations, such as heteroatom-heteroatom, carbon-carbon, carbon-heteroatom of alkenes, can be used efficiently to achieve bond formations at vicinal positions. However, transition metal catalyzed arylphosphorylation and arylnitration of alkenes is quite challenging. This thesis describes these two transformations. This thesis is composed of three parts:1. The development and application of transition metal catalyzed difunctionalization of alkenes were summarized in detail. The scope of this review is more narrow, focusing sharply on difunctionalization of alkenes catalyzed by Pd, Cu, Fe, Ag catalysts. The reactions are classified by the metal types of catalyst, and introduced systematically.2. We descried a novel Ag-catalyzed arylphosphorylation of alkenes in detail. This reaction creates an opportunity to construct various diphenylphosphoryl oxindoles. Preliminary mechanistic studies indicate that the reaction might involve a radical process.3. We presented in detail a highly efficient AcOH/AgNO3promoted arylnitration of alkenes via a nitration and C-H functionalization cascade process, which is suitable for the synthesis of various oxindoles containing nitro group, transition metal-catalyzed arylnitration of alkenes is in progress.