Sc（OTf）₃-Catalyzed Dehydrogenative Cyclization To Synthesize Acridones And Catalyst-Free Three-Component Reaction To Synthesis Chiral α-Aminophosphine Oxides

The core content of this paper is that the synthesis of acridone and its derivatives, especially, we have developed a novel method of Sc(OTf)3-catalyzed aldehydes through intramolecular cyclization to synthesize substituted N-methyl acridones. At the same time, we have also developed a three-component system of Chiral Amino Acid Ester to construct chiral phosphorus compounds.This paper consists of three parts:The first part will introduce a branch of acylation reaction in organic synthesis. This branch is that transition metal catalyzed hydroacylation. In the catalyzed system of transition metal, we are focused on intramolecular alkene hydroacylation, intermolecular alkene hydroacylation, intramolecular alkyne hydroacylation and intermolecular alkyne hydroacylation.The second part is Sc(OTf)3-catalyzed dehydrogenative cyclization for synthesis of N-methyl acridones. The main content will cover the biological and pharmaceutical properties of acridone and its derivatives, the methodology of background, which contains a lot of teams to synthesis acridone and its derivatives in different methodologies, especially in recent years, many research group by metal catalyzed to build this kind of compounds. As well as it is also related to screening the optimum reaction conditions, the scope of substrates, the researching of kinetics experiment and reaction mechanism.The last part focuses on catalyst-free three-component reaction to synthesize chiral χ-aminophosphine oxides. Chiral phosphorus compounds play an important role in the synthesis of drugs and ligands. We will introduce the background of C-P bond formation, especially the construction of C-P bond by three-component system, and the use of some of the three-component system for the synthesis of chiral compounds. We summarized the advantages of this three-component system to construct chiral phosphorus compounds. At the same time, we revealed the process of screening the reaction conditions and to explore the scope of substrates.