| Objectives1To analyze the assessment standard usage of literature which treatment ankylosing spondylitis patient with Chinese medicine and to provide the help for the clinical.2Based on etiopathogenisis and pathogenesis of deficiency in kidney and Du Channel with cold type AS in traditional Chinese Medieine theory, building effacacy scale with Chinese characteristics of ankylosing spondylitis of deficiency in kidney and Du Channel with cold type AS which used to assess the clinical effectiveness in traditional Chinese medical treatment. Examining the reliability, validity and responsibility, search for the methods of clinical evaluation of Chinese medicine.3Detecting eficiency in kidney and Du Channel with cold type AS patients, healthy people and AS patients with non-eficiency in kidney and Du Channel with cold patients serum cAMP, cGMP, cAMP/cGMP to explore whether there are cAMP/cGMP imbalance in AS patient of eficiency in kidney and Du Channel with cold type, and thus explore cAMP/cGMP whether related with the integralof syndrome of eficiency in kidney and Du Channel with cold type AS. By detecting TPRACP5b, PKA indicators to explore the relevanting of the degree of deficiency in kidney and Du Channel with cold and bone metabolism.Methods1. The literature research on evaluation standard of TCM efficacy of AS. Collecting the years2000-2012randomized controlled clinical study of literature which treated AS patient with TCM and Integrative Medicine. Analysis usage situation of the efficacy evaluation of AS 2.Through expert advice and patient investigation, To establish the TCM syndromes evaluation scale for AS of kidney empty and DU Channel cold and examine its scientificainess. Based on previous research, the questionnaire of Chinese medicine syndrome in AS was introduced as index item pool of syndrome outcome assessment for AS. The methods such as subjective evaluation, inspecting the distribution of entry, discrete trend, factor analysis, correlation coefficient, Cronbach’s a Coefficient, were applied to sift rating scale entry of Chinese medicine syndrome in AS, of which the reliability, validity and responsiveness were measured.3.Select30patient of the deficiency kidney the Du channel cold type for the experimental group and non of kidney deficiency cold type AS of30patients and10healthy people as a control group. Record AS patients age, gender, disease duration, BASDAI and BASFI scores of TCM. Fasting venous blood specimens were taken. The enzyme-linked immunosorbent assay in patients with AS and healthy people of cAMP, cGMP, cAMP/cGMP TRACP5b of PKA level. Compare the difference of each index, to analyze the relevance of each indicator and kidney Governor cold integral.Results1.The results suggested that there were many kinds of evaluation standards of efficacy of AS. Included80literature, the current efficacy evaluation of diabetic nephropathy is no uniform standard, The utilization of5.75%literature have no standard criteria,23.00%of the literature using self standards or reference, the2002"Principles "is widely used but accounted for only27.59%, other standard utilization of rate was lower than30%.2AS kidney Governor TCM syndromes cold syndrome rating scale initially established. According to TCM theory and AS-specific entry pool is first formed, through expert advice and patient investigation, the formation of22entries pools, cold syndrome of AS kidney Evaluation Scale Governor candidate entries. Using a variety of methods of mathematical statistics, namely the AS kidney Governor cold syndrome TCM Therapeutic Evaluation epidemiological data for statistical analysis of data from different angles, cold syndrome screening AS kidney Christ Evaluation Scale entries. Among them, the inspection method using the frequency distribution of entries focused perspective on trends in screening out16entries, using the correlation coefficient is a representative from the entry point to filter out of the20entries, discrete trends in France from the entry point of the sensitivity of screening the11entries, Cronbach coefficient method to filter out18entries, using factor analysis representation from the entry point screened out21entries. Integrated use of several methods to filter out by the joint pain, morning stiffness, lower back chills, chills, hands or feet are not warm, backache or knee soft, listlessness, spontaneous, frequently breathlessness9entries consisting of AS TCM.AS kidney empty and DU Channel cold TCM syndromes cold syndrome rating scale scientific assessment. Governor kidney collecting multi-center case cold type AS200people, the scale for validity, reliability of the scientific assessment, showing the feasibility of scales better, with good reliability and validity.3Reduce kidney Du channel cold AS patients than in healthy people and non-kidney Governor cold AS patients plasma levels of cAMP and cGMP levels, cAMP/cGMP ratio decreased, TRACP5b increased. ConclusionEstablished reliability and validity of AS kidney Governor cold syndrome TCM Therapeutic Assessment Scale. Governor Han patients with kidney cAMP/cGMP imbalance, but the extent is not yet cold kidney Christ through cAMP/cGMP to react. TRACP5b serum increased, but the symptom score and bone destruction was no significant correlation.Patients with kidney Governor cold presence of cAMP/cGMP imbalance. The cAMP/cGMP level not yet able to reflected Kidney and Du cold "degree". The elevated serum TRACP5b which shows the significance of the renal main "bone" theory, but not capable of reaction to the level of bone destruction and the symptom score. |
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