Clinical Observation And Experimental Study Of Hp Related Gastritis

ObjectiveBased on the collection of Hp related gastritis clinical case analysis, analysis of the clinical curative effect of traditional Chinese medicine for the treatment of Hp related gastritis; and through the Hp associated gastritis animal experiment, IFN-content, SlgA content of gamma ray in the serum of change, to explore the possible mechanism of traditional Chinese medicine in the treatment of Hp related gastritis among them.MethodsThis study is divided into aspects of clinical studies and animal experiments two:The clinical study90 cases were randomly divided into Chinese and Western medicine group and the western medicine group. Chinese and Western medicine group, the use of triple sterilization medicine:Omeprazole enteric coated tablets 20mg, amoxicillin capsule 1.0g, clarithromycin dispersible tablets 0.5g, Bid; the course of treatment was 10 days), and according to the Chinese medicine dialectical use of decoction of traditional Chinese medicine; the medicine group, omeprazole enteric coated tablets 20mg, Amoxicillin Capsules clarithromycin dispersible tablets 1.0g,0 5g,10 Bid; treatment day.The animal experimental study40 SD rats,40 rats were randomly divided into the blank group, model group, traditional Chinese and Western medicine group, the western medicine groupModeling methods:the first in NaHC03 solution and a Hp solution perfusing stomach, gastric lavage, every other day,5 times in a row.Interventions:blank group and model group given the same amount of white boiling water by gavage.Traditional Chinese and Western medicine group, daily Banxiaxiexin Decoction dose 8.60mg/g, amoxicillin gastric perfusion 0.22mg/g, seventh days of rest, take 12 days.The western medicine group, gavage daily amoxicillin 0.22mg/g, seventh days of rest, take 12 days.Results(1)The clinical research:two groups of 13C breath test results with no statistical difference, but combine traditional Chinese and Western medicine treatment group in the Hp eradication rate and reduce the incidence of adverse events has certain advantages.(2)The western medicine group, curative effect is better than western medicine group.(3)The content of serum of traditional Chinese and Western medicine in the group of IFN-gamma, SIgA better than western medicine group, the difference was significant (P<0.05).Conclusion(1) The traditional Chinese medicine combined with western medicine can improve the curative effect in patients with Hp associated gastritis.(2)The traditional Chinese medicine combined with western medicine can reduce the content of serum Hp associated gastritis model rats of IFN- gamma, SIgA, and good effect than the pure western medicine.