Research Into Professor Zhou Zhongying’s Clinical Experience And Academic Idea Of Treating Bronchopulmonary Carcinoma

This article is completed in author’s tutor guidance and in this article, the author probes Chinese medicine etiology, pathology, syndrome and treatment rules of bronchopulmonary carcinoma on the basis of the professor Zhou Zhongying’ clinical experience and academic idea in diagnosing and treating bronchopulmonary carcinoma for dozens of years. The article is divided into three parts and two attachments.In the introduction, the author concisely introduces the epidemiology, major risk factors, diagnosis and the treatment of pulmonary carcinoma. At the same time, the respective superiority and inferiority of TCM and modern medicine are also involved. Moreover, the author points out that Professor Zhou has accumulated affluent experience in the treatment of pulmonary carcinoma, so this study of his clinical experience and academic idea is very important, especially to development of TCM.In the first section, the author presents the cognition of pulmonary carcinoma in ancient medical classics. Although its actual name is not known in the past, the interrelated details are in all kinds of Chinese medicine, medical formulary and series. On the basis of ?Nei jing?. the doctor have recognized the etiology, pathogenesis, syndrome, prognosis and treatment of this disease, otherwise, they develop it throughout their clinical experience in preventing and treating pulmonary carcinoma. So the later have the important experience in the differentiation ? of symptoms and signs.In the second section, the author provides a systemic statement on the clinical experience of Professor Zhou on treating pulmonary carcinoma. In this article the author also presents respectively the pathogenesis, differentiation of symptoms and signs, syndrome, therapeutical principle and empirical medication. In the pathogenesis, the difficiency of qi due to cancerous toxin is the basis of morbidity; cancerous toxin may result from the external invasion and internal injury due to emotional disturbance, improper diet and deficiency of Zangfu organs. Obstruction of the lung by cancerous toxin is the key of pathogenesis. Therefore the author concludes that cancerous toxin is the primary pathogenic factor. Stagnation of cancerous toxin, phlegm and blood stasis are the key causative factors for the occurrence of pulmonary carcinoma. Obstruction of the lung by cancerous toxin leads to the basic pathological change. For the pulmonary carcinoma, the lung is the main organ invaded, but the liver, spleen and kidney may also be involved. Pulmonary carcinoma is characterized by a deficiency-excess complex, asthenia in origin and sthenia in superficiality. In the main points of differentiation of symptoms and signs, the author discusses it in six point (etiopathogenisis, staging of disease, pathogenesis, the main sign, position, prognosis). In the appearance of this disease, the author summarizes 6 points (accumulation of virulent heat syndrome, asthenia of spleen and retention of phlegm syndrome, qi stagnation and blood stasis syndrome, yin asthenia and endogenous heat syndrome, asthenia of both qi and yin syndrome, asthenia of both lung and kidney syndrome) and analyses common symptom briefly; In the points of therapeutical principle, the author summarizes the treatment of professor Zhou binding with typical example, and thinks that "At the initial stage, the body resistance is stronger while the pathogenic Qi is weaker, so attacking method should be adopted immediately. At the middle stage, the pathogenic Qi becomes stronger while the body resistance is weakened, so both attacking and tonifying methods should be applied. At the later stage, the body resistance becomes deficient while the pathogenic Qi is excessive, so tonifying method should be used with assistance of attacking". According to the pathological syndromes of pulmonary carcinoma, the following four methods should be taken: resisting carcinoma cells and relieving toxin, transforming phlegm and dissipating masses, regulating qi and quickening blood, and strengthening healthy qi. Because the common clinical symptom of pulmonary carcinoma are cough, expectoration, dyspnea, hemoptysis, chest pain, fever, emaciation and weakness. At the same time, retention of fluid in the chest and celostomia are the conventional complication, so we should distinguish its cause carefully and treat with syndrome differentiation. We can adopt some therapies as follows: dispersing and descending the lung Qi, checking cough and transforming phlegm; descending Qi and transforming phlegm, assisting the kidney to hold Qi and smoothing asthma; cooling blood and checking bleeding, descending Qi and reducing fire; moving Qi and dissipating masses, moving blood and relieving pain; moistening Yin and clearing heat, relieving toxin and protecting body fluid; invigorating Qi and nourishing Yin, supporting the body resistance and dispelling carcinoma cells; moving Qi and quickening blood, disinhibiting water and resolving fluid retention; moistening and nourishing the lung and kidneys so as to moisten the throat, and it is good to use the traditional Chinese patent medicine simultaneously, such as xiahung pill and Meihuadianshe pill. In the points of empirical medication, the author introduces the distinct drug to pulmonary carcinoma. Resisting carcinoma cells and relieving toxin drug, transforming phlegm and removing stasis drug, softening the hardness and dissipating masses drug are should be considered. And professor zhou also uses drug with symdrome differentiation. The author analyzes his experience based on up-to-date mechanism of drug action. The following drugs are commonly involved: Zhijiangcan, centipede, lu honeycomb, Hongdoushan, glabrous sarcandra herb, hedyotis diffusa, Baimao prunella vulgaris, cordate houttuynia, root of subprostrate sophora, black nightshade, globethistle; turtle shell, edible tulip, buttercup root, Ze Chatham, jack-in-the-pulpit, pinellia; pangolinscale, ground beetle, leech, zedoary turmeric, peach kernel, powder for dissipating blood stasis, sweetgum, leatherleaf milletia, corydalis, agalloch eaglewood; dangshen, radix pseudostellariae, milk veteh, job’s tears, Chinese caterpillar fungus; ladybell root, Beishashen, lucid asparagus, tuber of dwarf lilyturf, lily bulb, root of Chinese trichosanthes, fresh or dried root of rehmannia, fruit of Chipese wolfberry, goat, ghost buns; Chinese yam rhizome, rice sprout, mait, fruit of hawthorn, medicated leaven, membrane of chicken gizzard.In the third section, the author classifies data of 64 pulmonary carcinoma patients on clinic cured by professor Zhou, summarizes and have a statistical analysis result. Then the author observes the distributed rate of syndrome, essential, symptom, drugs of dispelling repletion and tonifying vacuity. So the author can prove up the basic appearance of this disease, empirical medication and induce the therapeutic experience and unique treatment of professor Zhou about pulmonary carcinoma, such as: combining syndrome differentiation and disease distinguishing, methods of supporting the body resistance and attacking, part and whole; resisting carcinoma cells and relieving toxin from beginning to end, eliminating phlegm and removing blood stasis flexibly, ordering compound methods and complex prescription, compatibility of medicines according to the seven emotions, seeking pathogenesis by analyzing syndrome and determining treatment and the used prescriptions, attacking toxin with toxicant drugs, more heat and less chills and using pyretic tonification cautiously, protecting gastric qi constantly, making use of worm to resist carcinoma cells and relieve toxin proficiently, et al.In the attachment one, the author reviews the current situation and important development of the prevention and therapeutics of pulmonary carcinoma in TCM that we have recently achieved, including research of etiology and pathogenesis, syndrome differentiation, therapy, special prescription and medicine, resisting carcinoma cells dmgs in common usage and so on. Although Chinese medicine can increase healing efficacy, reduce toxicity, improve symptoms, raise quality of life (QOL) and prolong surviving period, there are many questions, too. For instance, the pathological investigation of pulmonary carcinoma is still stopped at concluding summing-up ancestor observation, probing and validating phase, and has no uniform differentiantion of symptoms and signs now. The scholars sum up the treatment experience differently, but consistent recognition hasn’t produced. So it is necessary to discussing pathology of pulmonary carcinoma and exploring effective treatment methods.In the attachment two, the author states recent advances of pulmonary carcinoma, including surgical operation, chemotherapy, radiotherapy and biological therapy, et al. It is pointed out that the multi-modality treatment can have a good effect, accompanying with upgraded techniques of surgical operation, chemotherapy, radiotherapy and biological therapy. However, the direction of the treatment research of pulmonary carcinoma is going to develop new particular, targeted, highly active and low toxic dmgs of resisting carcinoma cells.Guided by Chinese medicine theory and combined with new progression of modern medicine, the article conducts a deep-going research on pulmonary carcinoma and gives emphasis to the overall concept and syndrome differentiation. The author induces the etiology, pathology, syndrome differentiation and treatment rules of pulmonary carcinoma by studying cancerous toxin, analysis of clinical cases, and provides the theory basis and effective prescriptions and dmgs on the basis of professor Zhou Zhongying’s clinical experience and academic idea in treating pulmonary carcinoma.