Research On Theory And Test Of Taijiquan “Five Gong Six Fa” As Adjuvant Therapy On Early Parkinson’s Disease

Objective:Exercise is medicine. Being an ancient Chinese martial art, Taijiquan has been taking very important position in “National Fitness Plan”. Helping to promote physical and mental health,Taijiquan is known as the most effective medicine to preven modern civilization disease. Parkinson’s disease(PD) is a common neurodegenerative disease in the central neural system. People in the elderly over the age of 65 incidence of Parkinson’s disease of 1~2%, the average age of onset are about 55 years old. At present, There will being many various methods and ways to treating PD to increasing with widely and deeply researching on the PD, but the medicine of treating PD was still main method. These drugs were found only partly alleviates symptoms instead of having the ability to affect the development of the disease. Their benefits also tend to wax and wane as the disease progresses. Moreover, toxicity and side effect tend to rises with the increment medication time and number of drugs used. Other treatments are expensive and can’t get rid of the problem such as drug dependence. There is now a body of evidence showing that exercise has the protective effects on brain. Especially for older adults, exercise played a big part in protecting brain.” Play boxing without internal, you will get nothing”. As classic Gongfa, “Five Gong six fa” of Taijiquan plays a vital role in fitness. Therefore, it’s necessary to have deep analysis and research on “Five Gong six fa” of Taijiquan effect on early Parkinson’s disease in the light of exercise and early prevention of chronic diseases. To explore the influence of “Five Gong six fa” of Taijiquan on the nerve growth factor and insulin like growth factor binding protein 1 of early PD patients. Study the improvements of behaviors and symptoms of early PD patients that practice “Five Gong six fa”. Both new ideas and theoretical are to provide for exercise prevention of PD.Methods:The literature material law, Expert interview method, experimentation and mathematical statistics are used. Traditional medicine, modern medicine, health science, exercise physiology, sports biochemistry are used to study on theoretical analysis and experimental research of exercise intervention of “Five Gong six fa”for early PD.Results:Part 1Theoretical study:(1) Kidney and liver deficiency are germane to early PD, based on such points as age of onset, location, symptoms, content of striatal dopamine and treatment. The occurrence of PD is a gradual process, kidney deficiency then liver deficienc and clinical symptoms of relationship in turn.(2) Regulating Yin and Yang, Enhancing the viscera function, promoting redox equilibrium of the organism are the ways to achieve both yin and yang in of early PD patients.(3)Taijiquan make the body Yi, Qi and Xing unity by adjusting heart,breathe and body harmony and make the body’s internal organs and movement influence each other of the PD patients to promote each viscera to harmony, that takes the body Yin Ping Yang Mi to make their physical health.(4) Inferred by theory, the PD patients’ s dopaminergic neurons may be protected and reduced the apoptosis by the exercise intervention of Taijiquan. Taijiquan can also promote the production of dopamine and effect Iron metabolism of dopaminergic neuron, improve the clinical symptom in PD patients.Part 2 Experiment results:(1) The effect of Taijiquan “Five Gong six fa” on behavior of patients with early PD is embodied in the score of balance and motor function. ①Berg balance scale score of patients with early PD display: T2 > T1, with significant difference(P < 0.01); T3>T1 has a very significant difference(P<0.01); T3 >T2, with significant difference(P< 0.05); T4>T3, with significant difference(P<0.05).②UPDRS(III) score of patients with early PD display: T2<T1, with significant difference(P < 0.01); T3 < T1 had a very significant difference(P<0.01); T4 < T3, with significant difference(P < 0.01); T3>T2, with significant difference(P < 0.05).(2) The effect of Taijiquan “Five Gong six fa” on serum biochemical indexes in patients with early PD is embodied in changes in Tyrosine hydroxylase(TH), Homovanillic acid(HVA), Insulin like growth factor(IGF-I), Nerve growth factor (NGF) and Glutathione peroxidase(GSH-PX).①TH)content in serum of Patients with early PD intervention in each stage: T2>T1,with significant difference(P < 0.05), T4>T3 with significant difference(P<0.05), the other groups had no significant differences(P >0.05).②HVA)content in serum of Patients with early PD intervention in each stage: T2 > T1, with significant difference(P < 0.05), T4>T3 have significant difference(P<0.05); but after the washout period, T3 < T2, subjects with HVA had significantly decreased, with a significant difference(P<0.05).③IGF-I content in serum of Patients with early PD intervention in each stage: T2>T1,with a very significant difference(P<0.01), T4>T3,with significant difference(P<0.05); but after the washout period, T3<T2, subjects with IGF-I had significantly decreased, with significant difference(P<0.01).④NGF content in serum of Patients with early PD intervention in each stage: T2>T1,with significant difference(P<0.05), T4>T3,with significant difference(P<0.05), the other groups had no significant differences(P>0.05). ⑤ GSH-PX content in serum of Patients with early PD intervention in each stage: T4>T3,with significant difference(P<0.05), the other groups had no significant differences(P>0.05).Conclusion:(1)Being a classical Gongfa of Taijiquan, Taijiquan “Five Gong six fa” is great to use as an adjuvant therapy on early Parkinson’s Disease. It could promote the homeostasis of the organism, relive Yinyangzihe and play a role in adjuvant therapy for early Parkinson’s Disease.(2)Taijiquan “Five Gong six fa” can improve the balance ability and motor ability of early PD patients. It has the assistance treatment for PD and the effect of intervention for a long time. But the long-term effect is limited, it will decline as the intervention stopping.(3) Taijiquan “Five Gong six fa” can enhance the ability of DA neurons to against oxidative stress of PD.Suggest: Non-motor symptoms like cognitive impairment, one of the most marked characteristic of Parkinson’ disease, contribute to increased disease burden and decreased quality of life. cognitive impairment in PD is characterized by involvement of memory,attention, executive function, visuospatial functioning and language. cognitive impairment may be persistent in nature along the disease. Research indicates that mentality and society acclimatization can be improved by taijiquan. For the future, widen the view of research in using taijiquan “Five Gong six fa” as a way to interfere the non-motor symptoms like cognitive impairment and enhance the QOL of patients of PD.