Gastrointestinal Stromal Tumors And Clinical Pathology And Prognosis Of Nutritional Risk Assessment Of Gastric And Esophageal Cancers

Objective:On185cases of the analysis to explore the impact of gastrointerstinal stromal tumors prognostic factors.Methods:A total of185patients with GIST underwent primary surgical treatment from January2000to December2010at Perkin Union Medical Collage Hospital.Results:Univariate analysis revealed that tumor size, mitotic count, tunor location,2008NIH consensus criteria for risk stratification, Ki-67index are related to the tumor free survival rate. Multivariate analysis showed that mitotic count, tunor location are independent prognostic factors. And among the79high-risk cases, the results showed that tumor free survival rate of the Gleevec adjuvant therapy group(26cases) is significantly higher than that of non-Gleevec therapy group(53cases).Conclusion:Tumor location and mitotic count are independent prognostic factors of GISTs. Targeted therapy with imatinib can improve tumor free survival rate in high-risk GISTs. Objective:To examine the expression of CENPF and c-met in gastrointerstinal stromal tumors and evaluate the relationship with clinicopathological parameters and prognosis.Methods:A total of44patients with gastric or interstinal GIST underwent surgical resection from Jan2001to Feb2007were included. Expression of CENPF and c-met was determined by immunohistochemistry. The relationship between CENPF and c-met expression and clinicopathological and prognostic variables were evaluated.Results:The expression ratios of CENPF and c-met in tumor were25.0%and59.1%respectively. Positive expression of CENPF in tumor tissues were usually with interstinal location, larger size, higher mitotic count and higher risk stratification. Univariate analysis showed that GISTs with positive CENPF expression had significantly lower tumor-free survival rates, compared with those with negative expression. Multivariate analysis revealed that CENPF was an independent poor prognosticator in gastric or interstinal GIST. Expression of c-met was not correlated wlth clinicopathological variables and prognosis.Conclusions:Expression of CENPF is correlated wlth tumor size, tumor location, mitotic count, risk stratification and tumor recurrence. CENPF is an independent poor prognostic factor in gastric or interstinal GIST. Expression of c-met was not correlated with clinicopathological variables and prognosis. Objective:To evaluate the rate of nutrition risk in pre-operation patients with gastric cancer and esophageal cancer by NRS-2002, to assess the correlations betvveen nutrition risk and nutrition related to hemoligical levels, application of nutrition support and health economic indexes.Methods:Patients with gastric cancer and esophageal cancer in surgery department were included from Oct2011to Apr2012and evaluated by NRS-2002preoperatively. Data also was recorded on nutrition related hemoligucal levels, applications of nutrition support and health economic indexes.Results:The rates of nutrition risk in gastric cancer and esophageal cancer were54.0%and60.0%respectively. The rate in elderly gastric cancer patients was93.3%, higher than that of not elderly(37.1%). The average levels of albumin, prealbumin, lymphocyte count in gastric cancer cases with nutrition risk were lower than that of without nutrition risk. And the albumin, hemoglobin, erythrocyte count mean values in esophageal cancer cases with nutrition risk were lower than that of without nutrition risk. The health economic indexes of gastric or esophageal cancer patients tended to increase in those with nutritional risk. There is a downward trend of health economic indexes in cases with preoperative nutrition support amonog patients with nutritional risk. But the tendencies were not statistically significant.Conclusions:Patients with gastric cancer or esophageal cancer had a high nutrition risk rate. Older patients with gastric cancer got a higher nutrition risk rate. Preoperation nutrition support didn’t increase the health economic indexes among patients with nutrition risk.