Theoretical And Experimental Study Of Shengqingjiangzhuo Recipe In Protecting Nerve Injury Of Cerebral Ischemic Stroke

Aim：To observe the theoretical mechanism of cerebral ischemic stroke,advances inthe treatment of cerebral ischemic stroke,and the protection of Shengqingjiangzhuo Recipeon nerve cells of focal cerebral ischemic rats.Methods：Established MCAO rats model with suture for expriment,and the rats weredivided into model group,sham-operated group,the group of western medicine,thelow-dose and high-dose groups of Chinese medicine.We observed the neurobehavioralscores,the effection on brain CT,the NO,ET-1,central neurotransmitter(Glu、Asp)changes measured by immunohistochemical method,chemical method.Results：After treatment of20days,Shengqingjiangzhuo Recipe could improve theneurobehavioral scores in rats,reduce the lesion size on brain CT,reduce the content ofbrain excitatory amino acids(Glu and Asp),increase serum NO concentration,reduce theET-1expression.Conclusion：Shengqingjiangzhuo Recipe could improve motor function of MCAOrats,enhance the protection mechanisms of nerve cells,significantly reduce the nerveinjury of cerebral ischemic stroke.