The Therapeutic Mechanism Of Yiqihuoxuelishui Recipe On Middle Cerebral Artery Occlusion Ischemic Rats

Aim: To observe the Yiqihuoxuelishui Recipe on nerve cells of focal cerebral ischemic rats. Methods: Established MCAO rats model with suture for expriment, and the rats were divided into model group, sham-operated group, the group of western medicine,the low-dose and high-dose groups of Chinese medicine. Brain CT, central neurotransmitter (Glu,Asp,Gly), NO, ET-1 ,BNP changes were measured by immunohistochemical method,chemical method,imaging means. Results: After treatment of 20 days, Yiqihuoxuelishui Recipe could significantly reduce the lesion size on brain CT,improve the neurobehavioral abnormalities in rats, reduce the content of brain excitatory amino acids (Glu and Asp),and reduce the content of Gly ,increase serum NO,BNP concentration,reduce the ET-1 expression, obviously improve the pathomorphology changes of nerve cells. Conclusion: Yiqihuoxuelishui Recipe could significantly reduce the nerve injury of ischemic stroke, enhance the protection mechanisms of nerve cells, which play a role of anti-injury and cerebral protection.