Clinical Analysis Of2440Cases Of Non-small Cell Lung Cancer

Objective:To summarise the clinical results of treatment of2440cases of non-small-cell lung cancer from our hospital over a period of8years, investigate the clinical characteristics of each stage and prognostic factors, and treatment impact on prognosis, used to guide clinical practice, provide the basis for the prospective clinical study.Methods:2440patients with non-small-cell lung cancer treated at our hospital were enrolled in this study.The histology of the tumor was described according to the World Health Organization ciassification,and the stage was defined by the7th edition of UICC-TNM staging system.We analyzed the relationship between different modalities of treatment and survival, and evaluated a number of prognostic variables for overall survial including gender, age, cigarette consumption,tumor family history, living circumstance, performance status score, degree of tumor differentiation, targeted therapy, pathological type, tumor staging, treatment manners,type of surgery,concurrent chemoradiation etc.Results:The overall1.3,5year survial rate was68.1%,20.4%,13.3%, respectively.The median survial time was13.2months,and the median progress free time was8.6months.Cox regression indicated that PS0-1points,histology, tumor staging, surgical treatment, radiotherapy, platin-containing chemotherapy, complete remission, partial remission, the number of resected lymph nodes≥10and time to progression>6months were the prognostic factors of patients with non-small-cell lurig cancer.Conclusions:1. PS0-1points, the number of resected lymph nodes≥10and time to progression>6months were the independent prognostic factors of patients with non-small-cell lung cancer. Pathological type,tumor staging, surgical treatment, radiotherapy, platin-containing chemotherapy, complete remission and partial remission as independent prognostic factors consistent with those reported literature.2. Means of diagnosis, type of surgery, adjuvant chemotherapy for stage IB, the total number of chemotherapy cycles, the total number of chemotherapy drugs, targeted therapy and concurrent chemoradiation had the correlation with the long-term survival of the patients with non-small cell lung cancer.3. Family history, odd and even second-line drug treatment, efficacy of three-line therapy,time to progression of three-line therapy did not affect the prognosis of the patients with non-small cell lung cancer.